Our best suggestion is gradually. For each person is unique with a unique physiology, it is best to err on the side of caution when taking new supplements. For this reason, you can contact your doctor to find out what dosage is right for you. Some people start out with a small dose, maybe ¼ to ½ of the recommended dosage (1 capsule). Then increase slowly until you feel the effects at a desired intensity. We split the dose into multiple capsules so that you could more easily find an amount that works best for you. Please be cautioned that some effects take a whole month to make noticeable changes.