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Yes, but not all. Some pre-workouts contain caffeine, so it is best to avoid combining these with Infinergii since 4 capsules contain 150 mg of caffeine. Most other pre-workout supplements actually work synergistically with Infinergii. Infinergii increases the ability of the mind and the blood, but doesn’t nourish the body the way a pre-workout protein powder (such as creatine, for example) can.