Pramiracetam (also known as CI-879, Diisoprop-yl-(2-oxopyrrolidin-1-yl)acetamide, CI879) is a fat soluble nootropic. Pramiracetam is well-known as a system stimulant and a racetam molecule that was initially synthesized from piracetam due to its modifications having more anti-amnesiac potential in animals.[1]
Pramiracetam was first discovered by researchers at Parke-Davis, around then a division of Warner-Lambert, in the late 1970s. Though it was first tested with Alzheimer’s patients, seeing mixed results, it was then tried with major depressive disorder. Later this nootropic was tested for restoring cognitive function after stroke or traumatic brain injury.[2]


Pramiracetam is particularly effective at expanding correspondence inside your mind, helping your neurons to shape new associations which make it easier for you to learn and frame new memories. This Nootropic is additionally known to expand sharpness, capacity to focus and mental vitality making it simpler to remain focused and dynamic at school or work.  However, this supplement lacks enough studies of human evidence to support its many benefits.
The common health benefits of Pramiracetam include:

  • Improves cognitive function [3]
  • Improves memory [4]
  • Increases high affinity choline uptake (HACU) [5]
  • Helps people who have Alzheimer’s disease [6]
  • Expands learning capacity [7]
  • People report that it increases mental alertness, focus, rapid idea formation, and clear thinking

This Nootropic has been revealed to help the elderly and intellectually impaired youth in memory development. In any case, we perceive that most of the Nootropic users are ordinary, healthy persons who are quite recently attempting to get somewhat of a mental edge. One of the mental edges a person will get from Pramiracetam is enhanced memory.

How it works

The mechanisms of pramiracetam are not well known. Most Racetams work by directly refreshing particular neurotransmitter receptor destinations and in this manner expanding creation and discharge of particular neurotransmitters. However, Pramiracetam doesn’t straightforwardly bring about changes in neurochemical levels, and it doesn’t seem to have a similarity for any significant neurotransmitter. The direct activity of Pramiracetam is to increase choline uptake in the hippocampus (this is the part of the brain that works with recollection). Choline is a pioneer of acetylcholine, a neurotransmitter significantly engaged in psychological procedures including learning velocity, memory, and focus. By stimulating choline uptake, Pramiracetam ultimately adjusts the discharge of acetylcholine and stimulates expanded action in the hippocampus.
Pramiracetam may have different mechanisms of activity also. Specialists have estimated that besides its impact on the brain, Pramiracetam acts in peripheral destinations outside the brain that depend on the adrenal organs. The Animal study recommends that Pramiracetam may likewise increment or reestablish mind layer ease, which encourages cell signaling.
However, a study concludes about the mechanism of action of pramiracetam that, with its effect, it can be at least partially responsible for the enhancement of cognition processes.[8]


Similar to the instance of all Racetam Nootropics, the most widely recognized side effects related to Pramiracetam are headaches, uneasiness, nervousness and exhaustion. Since Pramiracetam is exceptionally all around endured and non-poisonous, the vast majority of these symptoms just present themselves if users take more than the prescribed dosage.


From studies that have been done, scientists have reached the conclusion about Pramiracetam dosage that 1200 mg for every day is the perfect dosage. You can separate this into three measurements of 400 mg or two dosages of 600 mg – both have been observed to be helpful. Try not to surpass these suggestions unless under specialists orders.