Phosphatidylserine, or PS, is a phospholipid that has both amino acids and fatty acids which are found in every cell membrane in the human body. The human body can make phosphatidylserine, but it obtains most of what it requires from foods. Phosphatidylserine (PS) is very important for cognitive function. The supplementation in older people helps improve memory and cognitive capacity.[1]


As a Nootropic supplement, Phosphatidylserine provides benefits for a number of cognitive processes. It is particularly well-known for having a helpful influence on memory and learning capacity along with boosting up memory recall. Phosphatidylserine supplementation might be a safe and natural nutritional strategy for improving mental performance in young children suffering from ADHD. The common health benefits of Phosphatidylserine include:

  • Improves cognitive performance in elderly [3]
  • Helps people with Alzheimer’s disease [4]
  • Improves memory [5]
  • Effective for depression [6]
  • Helps people with Parkinson’s disease [7]
  • Helps with Attention deficit hyperactivity disorder (ADHD) [8]
  • Improve athletic performance [9]

It is also well-tolerated both by healthy adults and elderly patients with heart disease, high blood pressure, and a number of other medical conditions and issues. There is also a lot of evidence showing that Phosphatidylserine is effective at decreasing stress and anxiety levels. Continued usage can defend against some of the factors related to senile dementia and memory loss.
Phosphatidylserine supports human cognitive functions, including the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories, the ability to retrieve memories, the ability to learn and recall information, the ability to focus attention and concentrate, the ability to reason and solve problems, language skills, and the ability to communicate. It also supports locomotor functions, especially rapid reactions and reflexes. [10]

How it works

Phosphatidylserine is an important chemical with extensive functions in the body. It is part of the cell structure and is a key in the maintenance of cellular function, especially in the brain.[2] Phosphatidylserine shows multiple mechanisms of actions within the brain. One of the most important things it does is to help the brain metabolize glucose and discharge and bind with a number of neurotransmitters.
It is known in order to increase Acetylcholine function that plays a vital role in many different cognitive processes such as memory, reasoning, focus, and sensory perception. Phosphatidylserine supplement is also observed to enhance the number of membrane receptor sites known as synapses. This can improve the quality and effectiveness of communications between brain cells.


There may be a few side effects along with Phosphatidylserine supplement although they are generally quite rare and mild. When overdosed, especially at doses over 300 milligrams, it may cause insomnia and stomach upset or other GI issues.
While combining it with natural blood-thinning supplements like ginkgo biloba, you have to be cautious. Speak with your doctor before taking PS if you have a chronic medical condition or are trying to conceive, pregnant, breast-feeding, under the age of 18 or taking other medications.[11]


A standard dose of Phosphatidylserine (PS) is 100mg, taken 3 times a day to total 300 mg daily. This dose seems to be effective as a daily preventative against cognitive decline, and 100 mg once daily may provide some degree of benefit. It is recommended for the children for the purpose of attention improvement to use 200 mg daily.