Whats is Nicotine?

Nicotine is a powerful parasympathomimetic stimulant drug with nootropic mechanisms of action and an alkaloid found in the nightshade family of plants. It is an active but addictive ingredient found in cigarettes and most tobacco products. There are certain nicotinic receptors in the brain for the neurotransmitter acetylcholine as they are also stimulated by interaction with nicotine. Though we all are aware that nicotine is the primary reason for addiction to smoking cigarette or other tobaccos, Nicotine may actually have medicinal benefits for a number of conditions including performance-enhancing effects on cognition, alertness, and focus.[1]

Nicotine health benefits

Nicotine, like many nootropics, has been widely used for its some interesting health benefits. The most common health benefits of nicotine include –Reduces anxiety and depression [6] Protects you against diseases like Alzheimer’s [7] Helps people who have Parkinson’s Diseases, Tourette’s and schizophrenia [8] Helps with ADHD [9] Improves cognitive functions like memory, attention and psychomotor speed [10] Develops the growth and health of blood vessels [11][12] Helps control diabetes [13]Nicotine works to increase the number of nicotinic receptors in the brain and influences the production and release of Acetylcholine, an important and powerful brain chemical known as a neurotransmitter which helps protect against the risk for Alzheimer’s disease. Nicotine, especially in the form of tobacco smoke, has also been shown to help with Parkinson’s disease by playing a role in inhibiting the activity of monoamine oxidase B (MAO-B). Besides the purely recreational appeal as a mild stimulant with its calming effects, many consumers find nicotine helpful for improving productivity, combating anxiety, and aiding mental focus. Many people who suffer from clinical and subclinical levels of depression, attention deficit disorders, schizophrenia, and other conditions find relief in smoking, apparently mostly or entirely because of the nicotine delivery. Some of these benefits are akin to those from one of the other most popular drugs, caffeine, though many users find the benefits of nicotine to be particularly appealing.

How Nicotine works

Nicotine works as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits (nAChRα9 and nAChRα10) where it works as a receptor antagonist.[3] There are certain delivery methods of nicotine, but it normally enters the body through inhalation, then it is absorbed into the bloodstream and crosses the blood-brain barrier. As soon as nicotine is smoked, it reaches the brain and enters into the central nervous system within about 15 seconds, but the elimination half-life is about 2 hours. Nicotine is metabolized in the liver and the oxidative metabolism of nicotine tends to become inhibited by menthol, an element included in a number of cigarettes, increasing the half-life. The amount of nicotine absorbed by the body from smoking can depend on many factors, including the types of tobacco, whether the smoke is inhaled, or a filter is used. On the other hand, it’s been found that the nicotine yield of individual products has only a small effect (4.4%) on the blood concentration of nicotine.[4]Nicotine reduces body weight by increasing energy expenditure and inhibiting the expected compensatory increase in caloric intake.[5] Though some people say that nicotine may be helpful for enhancing creativity, two recent studies involving nicotine’s effect on creativity found the relationship to be inconsequential.


Having addictive properties, it can’t be medically responsible for anyone to recommend nicotine. The deadly dosage for humans can be within the range of 30 to 60 mg. This is a rather high toxicity, even in comparison with hard drugs like cocaine. Be careful if you use patches and or gum, since it is definitely possible to take too much and suffer the consequences.