Grape Seed Extract


Grape Seed Extract, (Latin Name: Vitis vinifera), is a dietary supplement that is rich in powerful antioxidants and natural plant compounds named oligomeric procyanidins/ proanthocyanidins (OPCs) molecules (the two terms are used interchangeably).  Grape Seed Extract is derived from the ground-up seeds of red wine grapes and well-known for its medicinal and nutritional value for thousands of years. It is also prominent for its having some nootropic benefits to offer and plays an important role in preventing cancer, bone strength, oral health, healthy blood pressure, and Alzheimer’s disease.[1]


With immense potential health benefits, Grape Seed Extract is now used by people to relieve them of a number of diseases.  Its anti-inflammatory agent and antioxidant compound can protect your cells from external damage and help keep them properly maintained. It can also support metabolic function and control blood sugar levels. The most common health benefits of Grape Seed Extract include –

  • Increases Cognitive Function [5]
  • Promotes Brain Health and Eye Health [6]
  • Improves Cardiovascular Function [7]
  • Reduces signs of aging and Improves Skin Conditions [8]
  • Helps people who have Alzheimer’s Disease [9]
  • Reduces Stress [10]
  • Effective for Cancer [11]
  • Improves Alertness, Memory and Learning [12]
  • Users report it promotes Longevity and Improves Energy
  • Protects Against Bacterial Infections [13]
  • Stabilizes Blood Sugar Levels and Relieves Diabetes, Cholesterol and Edema [14]

There are several other health benefits associated with Grape Seed Extract supplement such as atherosclerosis, poor circulation, complications associated with diabetes, constipation, gastrointestinal disorders and even age-related macular degeneration.
When you are a nootropic user and you are interested in life extension supplements, this one will be an excellent supplement to try adding to your daily stack.[2][3]

How it works

Grape Seed Extract is derived from grape seeds which have a strong concentration of vitamin E, flavanoids, linoleic acid, and phenolic compounds known as Oligomeric proanthocyanidins (OPCs). The supplement has a number of different mechanisms of action to work. The flavanoids and polyphenols are considered to be such compounds which are the most active and cause effects. They both primarily work as antioxidants. They are able to eat up free radicals and remove many different types of chemicals and compounds from the body.
The most important component of Grape seed extract is Resveratrol, also known as 3,5,4′-trihydroxy-trans-stilbene. Resveratrol has great effects as an anti-cancer, anti-inflammatory, and antioxidant, as well as on stabilizing blood sugar levels and improving cardiovascular function.
Procyanidins from Grape Seed, in studies, have been shown to exert anti-oxidative effects in vitro in PC12 neurons, and can fully protect H2O2 induced cytotoxicity at a certain concentration without negatively affecting cell viability. Grape seed extract is also shown to protect cells from cytotoxicity induced by beta-amyloid pigmentation. In reference to a different study, feeding a strain of animals, especially mice with Alzheimer’s-like cognitive deficits, Grape Seed Extract (GSE) daily at a certain concentration for 5 months found notable cognitive improvement.[4]


Though Grape Seed Extract is generally considered safe, it has relatively a few side effects. The most common ones may include headache, itchy scalp, dizziness, sore throat, stomach ache and nausea. However, anyone with an allergy to grapes should avoid using this extract in any form.


You are recommended to take 100 mg to 300 mg of Grape Seed Extract daily as a standard dosage. As with many supplements, it is usually recommended to start with a lower dosage and then increase when tolerable. It is not recommended to take more than 300 mg unless your doctor advises you to do so.