[vc_row][vc_column offset=”vc_col-md-offset-1 vc_col-md-10″][vc_custom_heading text=”Colouracetam” font_container=”tag:p|font_size:75|text_align:center|color:%230c0c0c|line_height:1.3″ google_fonts=”font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal” css=”.vc_custom_1526905244957{margin-bottom: 100px !important;}”][vc_row_inner css=”.vc_custom_1507817140639{margin-top: 60px !important;}”][vc_column_inner width=”1/2″ offset=”vc_col-md-5″][vc_custom_heading text=”Background” font_container=”tag:p|font_size:50|text_align:left|color:%23c1c1c1|line_height:1.4″ google_fonts=”font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal” css=”.vc_custom_1517289513107{margin-top: 0px !important;margin-bottom: 30px !important;}”][vc_column_text]
Coluracetam (full structural name of 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro2,3-b quinolin-4-yl)acetoamide, and codenames of MKC-231 or BCI-540) is one of the newer nootropics belonging to the racetam chemical family- a group of substances with pro cognitive and neuro-protective properties. It is well-known for its cognitive enhancement effects based on the ways in which it influences choline uptake. Though coluracetam was first synthesized in Japan for its effectiveness in Alzheimer’s disease treatment, it appeared to be more effective as a nootropic and is purely marketed as a cognitive enhancer.[1]
[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/2″ offset=”vc_col-md-offset-1 vc_col-md-5″][vc_single_image image=”2528″ img_size=”large” alignment=”center”][/vc_column_inner][/vc_row_inner][vc_custom_heading text=”Benefits” font_container=”tag:p|font_size:50|text_align:left|color:%23c1c1c1|line_height:1.4″ google_fonts=”font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal” css=”.vc_custom_1517289491888{margin-top: 50px !important;margin-bottom: 30px !important;}”][vc_column_text]The nootropic supplement Coluracetam has been popular among the users for its various exciting benefits and one of which is its possible long-term improvements in memory-impaired individuals. As there has only been a limited amount of human testing at this point, the animal experiments serve as the best evidence of possible benefits. It is regarded twice more effective than noopept or piracetam. The most common health benefits of Coluracetam may include:

  • Improves cognitive performance [3]
  • Enhances brain power [3]
  • Improves memory, learning and mood [3]
  • Improves the HACU system by enhancing the signaling of high-affinity choline transporters [4]
  • Is used in the treatment of schizophrenia [3]
  • Reduces depression and anxiety [5]
  • People report it increases energy [6]
  • Improves focus, memory, motivation and wakefulness [7]

Coluracetam is used as a prophylactic treatment against or actual treatment of diseases of the central and peripheral nervous system, including degenerative, ischemic, learning, memory, mood, and anxiety disorders as well as trauma and psychosis.
Coluracetam enhances levels of choline in the brain and body and increases the production of acetylcholine without which we wouldn’t be able to remember the simplest of facts or move our muscles. Besides improving memory, it helps in many other functions including overall increasing speed of cognition and concentration levels.[/vc_column_text][vc_custom_heading text=”How it works” font_container=”tag:p|font_size:50|text_align:left|color:%23c1c1c1|line_height:1.4″ google_fonts=”font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal” css=”.vc_custom_1517289481425{margin-top: 50px !important;margin-bottom: 30px !important;}”][vc_column_text]The mechanism of action of Coluracetam differs from the mechanisms of the other substances from the racetam family (i.e piracetam). It appears to interact with a process known as high affinity choline uptake (HACU for short), which can be described as a “narrow throat” in the process of acetylcholine production. Increasing the effectiveness of this process translates into the increased activity of the acetylcholinergic neuron activity, so it is a desired target for cognitive enhancement.[2]
Coluracetam primarily works by enhancing choline uptake, meaning it enhances the overall level and efficiency of choline throughout the body. Choline is a precursor to the neurotransmitter acetylcholine and this hormone plays a crucial role in terms of memory, learning, as well as other cognitive effects. Coluracetam may also work based on AMPA receptors that influence glutamate in the brain. When your neurons make new connections, this is referred to as synaptic plasticity. Of all your neurotransmitters and brain hormones, glutamate is the most central within this process. As these new connections are formed, your brain is essentially making new memories.[/vc_column_text][vc_custom_heading text=”Considerations” font_container=”tag:p|font_size:50|text_align:left|color:%23c1c1c1|line_height:1.4″ google_fonts=”font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal” css=”.vc_custom_1517289526095{margin-top: 50px !important;margin-bottom: 30px !important;}”][vc_column_text]
Because of the inadequate history of this nootropic supplement, there isn’t a lot of definitive information regarding potential toxicity levels. Till now, this supplement appears to be safe based on the way it works within the body and brain as its effects and structure are similar to various popular, safe, and effective racetams. Though there are not noted side effects observed yet, you are suggested to consult your physician before taking Coluracetam.
[/vc_column_text][vc_custom_heading text=”Recommendations” font_container=”tag:p|font_size:50|text_align:left|color:%23c1c1c1|line_height:1.4″ google_fonts=”font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal” css=”.vc_custom_1517289542039{margin-top: 50px !important;margin-bottom: 30px !important;}”][vc_column_text]
There is not yet a medically recommended dosage for Coluracetam but most of the studies indicate that a dosage of approximately 200 mg per day would be helpful to the average person. Certainly, the dosage should also depend upon your reasons for taking the supplement in the first place. If you are suffering from major depressive disorder or general anxiety disorder, you are recommended to take up to 100 mg three times daily.
However, if you do not have as much experience with the supplement, you may find that starting with as little as 20 mg may give you positive effects. And then you can increase your dosage over time after developing a familiarity to the supplement.
[/vc_column_text][vc_custom_heading text=”Sources” font_container=”tag:p|font_size:50|text_align:left|color:%23c1c1c1|line_height:1.4″ google_fonts=”font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal” css=”.vc_custom_1517289552596{margin-top: 50px !important;margin-bottom: 30px !important;}”][vc_column_text] 

  1. https://examine.com/supplements/coluracetam/
  2. https://www.ncbi.nlm.nih.gov/pubmed/7710736
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326799/
  4. https://www.ncbi.nlm.nih.gov/pubmed/8740080
  5. https://pubchem.ncbi.nlm.nih.gov/compound/Coluracetam#section=MeSH-Entry-Terms
  6. https://www.longecity.org/forum/topic/70339-coluracetam-experience-reports/
  7. https://psychonautwiki.org/wiki/Coluracetam

[/vc_column_text][/vc_column][/vc_row][vc_row disable_element=”yes” css=”.vc_custom_1530127972989{margin-top: 70px !important;margin-bottom: 50px !important;}”][vc_column offset=”vc_col-md-offset-1 vc_col-md-10 vc_col-xs-12″ css=”.vc_custom_1520108245936{margin-top: 5px !important;}”][vc_custom_heading text=”Where to Buy” font_container=”tag:p|font_size:50|text_align:left|color:%23c1c1c1|line_height:1.4″ google_fonts=”font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal” css=”.vc_custom_1520108399874{margin-top: 0px !important;margin-bottom: 30px !important;}”][vc_row_inner][vc_column_inner width=”1/2″][vc_single_image image=”1327″ img_size=”medium” alignment=”center” onclick=”custom_link” img_link_target=”_blank” lazy_loading=”true” link=”http://amzn.to/2CW71cv”][vc_custom_heading text=”Please use our link to make your amazon purchases as we use the commissions to help fund our research projects which in the end help you and the rest of the uplifted community. We do not have any affiliation with the company providing the product that we are referring you to. Our decision to find the best on Amazon is completely based on our scientific testing methods here at Nootripure Laboratories.” font_container=”tag:p|font_size:13|text_align:left|color:%23bfbfbf|line_height:1.2″ use_theme_fonts=”yes”][/vc_column_inner][vc_column_inner width=”1/2″][vc_column_text css=”.vc_custom_1520108323227{margin-top: -15px !important;}”]Here at Nootripure Laboratories we like to test supplements for potency as part of our market research and competitor analysis. We already did the research so we figured we would share with you the best products for each supplement. All SAMe supplements are artificially manufactured as they can only be produced by the body. So all of them are generally similar. In this case we suggest going with a trusted brand that actually puts in the bottle what they put on the label. We get commissions on any SAMe supplement you buy on Amazon, but we would recommend the one in the link provided.[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row]