7-ketoDHEA

Background

7-keto DHEA (also known as 7-oxodehydroepiandrosterone or 7-oxo DHEA) is a derivative of DHEA. Actually, it is one of three oxygenated metabolites of DHEA, and these 3 oxygenated metabolites interconvert with one another but do not convert back into parent DHEA. However, by taking 7-keto supplementation, you can get all these 3 oxygenated metabolites without using DHEA.[1]
Unlike its “parent” hormone, 7-keto-DHEA does not affect sex hormone levels in the body. It is not converted into steroid hormones such as androgen and estrogen but it is being widely promoted as a means of accelerating metabolism in order to lose weight, specifically belly fat.[2] In fact, 7-keto seems to be a somewhat promising non-hormonal fat burning agent.

Benefits

7-KetoDHEA is a derivative of DHEA which occurs naturally and is produced in the skin, adrenal gland, and the brain. 7-keto DHEA is the most famous and valuable of the DHEA metabolites and has a lot of health benefits. Users report that 7-Keto DHEA greatly contributes to weight loss, muscle growth, increasing energy levels and may increase the metabolism in the body.
Actually, 7-keto-DHEA is taken by people to accelerate the metabolism and heat production to promote weight loss. 7-keto-DHEA is also used to improve lean body mass and build muscle, increase the activity of the thyroid gland, boost the immune system, enhance memory, and slow aging.[3]
The common health benefits of 7-Keto DHEA include:

  • Improves weight loss [4][6]
  • Increase metabolism [5]
  • Improves immune system of the body [7]
  • Increases general well-being [8]
  • Decreases blood pressure [9]
  • Acts as an anti-aging agent [10]
  • May improve cognitive function [11]

There are some other health benefits of 7-keto including improving the brain function done by helping the neurons to come in contact with each other that stops brain aging. The ingredient also works by increasing the activity of the thermogenic enzymes which are known for the oxidation of fatty acids.

How it works

7-ketoDHEA might promote weight loss by speeding up the body’s metabolism. In fact, as far as the effect of 7-keto DHEA on weight loss is concerned, the supplement has been shown to increase resting metabolic rate in participants who already were on weight-loss diets and were engaging in regular exercise. In the study, which lasted eight weeks, participants who took 100 mg of 7-keto DHEA twice a day lost about 6.3 pounds compared to a little over two pounds for those who received a placebo.[12]
7-ketoDHEA significantly decreases both ethanol-maintained and food-maintained responding, compared with the control, while also decreasing the blood ethanol concentration (BEC)[13]
While the direct effects of 7-ketoDHEA on the GABAA receptor have not yet been investigated, there is evidence that 7-ketoDHEA, like DHEA, reverses scopolamine-induced memory deficits in young mice. The proposed mechanism for this effect of DHEA, and presumably 7-ketoDHEA, is via the influence of GABAergic neurons on the cholinergic system (i.e., the reduction of GABAergic inhibition increases acetylcholine release and antagonizes the effect of scopolamine).[14]

Considerations

7-ketoDHEA is naturally safe. Some common side effects may be found there in using 7-Keto-DHEA. However, the most notable side effect that was recorded in a study was the elevation of the thyroid hormone. In an anecdotal report, it is found that when 7-keto is paired with exercise and diet, the results of fat loss were 3 times higher compared to not taking any other stimulant during weight loss.

Recommendations

A typical supplemental dosage of 7-ketoDHEA is 200-400mg daily in 2 divided doses (100-200mg) though some limited evidence suggests that lower doses of 50-100mg may be effective for neural purposes.
The optimal dosing schedule and overall dose of 7-ketoDHEA is not yet known, and the above dosages are just based on what is known to have efficacy.[15]
Still, you are advised to consult your doctor or healthcare provider to know the appropriate dosage for you.

Sources