Pantothenic Acid (Vitamin B5)


Vitamin B5, also called Pantothenic acid (a B vitamin), is a water-soluble vitamin. Vitamin B5 is important for the synthesis of acetylcholine (ACh), adequate levels of which can increase focus, memory, learning, and reduce brain fog.[1] Humans require Vitamin B5 to synthesize coenzyme-A (CoA) and also to synthesize and metabolize proteins, carbohydrates, and fats. Vitamin B5 or Pantothenic acid was discovered by Roger J. Williams in 1933. [2]


Vitamin B5 is a nootropic supplement and has numerous benefits like all other nootropic supplements. Vitamin B5 is greatly helpful to students and professionals who want to improve cognition, learning and memory as it raises acetylcholine levels in the brain.
Studies show that there are a lot of important B5 vitamin roles within the body, such as turning nutrients from food into energy, balancing blood sugar, reducing bad cholesterol, lowering high blood pressure, relieving nerve damage and pain, and also helping people who may have heart related problem.[ 3]
The common health benefits of Vitamin B5 include:

  • Improve cognitive function [5]
  • Promote learning and memory [6]
  • Reduce stress, anxiety and depression [7]
  • Promote alertness [8]
  • Relieve people of motion sickness and insomnia [9]
  • Relieve people of migraine headaches [10]
  • Help people who may have chronic fatigue syndrome [10]
  • Improves heart health [11]
  • Build stamina
  • Boost immune response [12]
  • Increase hemoglobin levels [13]
  • Promote skin health and hair health [14]

An important vitamin B5 advantage is that it helps the body generate red blood cells, which carry oxygen throughout our body.
Vitamin B5 or Pantothenic acid, as part of Coenzyme-A (CoA), is involved in the synthesis of the neurotransmitters acetylcholine, epinephrine, and serotonin that affect alertness, cognition, memory and mood. Vitamin B5 is standout for reducing stress, anxiety and depression.[4]

How it works

Similar to other B-vitamins, vitamin B5 plays a role in energy metabolism, acting as a coenzyme to energy-producing chemical reactions. It also plays a role in the synthesis of fat, hormones, and carbohydrates which we take in from the foods we eat, turning them into usable energy that the body uses in many ways. The energy that vitamin B5 helps to produce, is what fires the neurotransmitters in our brain. These neurotransmitters take chemical signals throughout our whole body to keep every system functioning appropriately. Because of this role, B5 vitamins are essential for maintaining the health of the nervous system.
Besides being important in producing red blood cells, vitamin B5 also plays a part in generating sex and stress-related hormones produced in the adrenal glands. Vitamin B5 is also crucial in maintaining a healthy digestive tract, improving immunity in the process. It importantly works with other B vitamins in the B Vitamin Complex, helping the body use other vitamins like riboflavin (vitamin B2).[3]


Side effects are rare but very high doses can cause stomach upset, nausea or diarrhea. While taking the antibiotic tetracycline, you should avoid using extra Vitamin B5 because it could counteract the effects of tetracycline.


While using any of the racetams like Piracetam and Aniracetam and using a choline supplement to raise acetylcholine levels, you absolutely need extra Vitamin B5 or Pantothenic acid. The recommended dosage of Vitamin B5 (Pantothenic Acid) is a 1 to 2 ratio with a choline supplement. For example, 250 mg of Vitamin B5 with 500 mg of CDP-Choline.[4]