Vinpocetine

Background

Vinpocetine is a synthetic organic compound derived from the periwinkle plant (specifically, synthesized from the molecule called ‘vincamine’) and has been used as a drug in Eastern European countries for the treatment of cognitive decline, stroke recovery, and epilepsy. Vinpocetine is also normally used as a nootropic compound to enhance blood flow and promote memory formation.[1] The first production of the synthetic version of Vinpocetine was started in 1978, in Hungary by a significant pharmaceutical company.

Benefits

Many scientific studies have shown vinpocetine to be of benefit for the inhibition and improvement of many different forms of ailments. It enhances cognitive functions, together with those involving long- and short-term memory, and it has also been shown to be valuable in protecting heart, visual, and hearing functions, among different benefits. The most common health benefits of vinpocetine include:

  • Improves cognitive performance [3]
  • Improves cerebral blood flow, brain metabolism, memory functions, and its neuroprotective actions [4]
  • Improves learning and memory [5]
  • Improves hearing health [6]
  • Helps with glaucoma [7]
  • Improve age-related macular decline [8]
  • Improves hearth health [9]
  • Helps people who have Alzheimer’s disease and dementia [10]
  • Helps people who have Parkinson’s disease [11]

Vinpocetine is neuroprotective. Vinpocetine may improve blood flow to the brain amd it’s used for enhancing memory and relieving of Alzheimer’s disease and different conditions that damage learning, memory, and information processing skills when people grow old. Vinpocetine is also used for relieving and reducing the possibility of disability and death from ischemic stroke which may happen when a blood clot stops blood flow within the brain, causing brain cells (neurons) to die as a result of they’re not receiving oxygen. Many people try vinpocetine for hindering stroke right after it happens as they think vinpocetine may help keep blood from curdling and may also defend neurons against the harmful effects of oxygen deprivation.
Vinpocetine is also used for relieving symptoms of menopause, chronic fatigue syndrome (CFS), and seizure disorders, and preventing motion illness.[2]

How it works

The mechanisms of vinpocetine are various. It seems to interact with many ion channels (sodium, potassium, and calcium) while tends to result in restrictive effects on neurotransmitter release and neuroprotection when dopamine or glutamate or salt are suppressed (these 2, when unnecessarily aroused by toxins, may cause oxidative damage). It also interacts with alpha adrenergic receptors and also the TPSO receptor, and whereas the precise benefit of these receptor interactions isn’t clear, they’re most likely relevant since they occur at the same concentrations that the ion channel interactions do.[1]
Overall brain metabolism is additionally improved because of the enhanced availability of glucose – the main energy source for the brain. With higher metabolism, Vinpocetine is able to positively have an effect on the ATP production in your cells. The result is a sense of mental clarity and also the alleviation of brain fog and fatigue.
Students say this nootropic permits them to study lots of material and retain much more of it compared to other stimulants like caffeine. Although caffeine is most typically used for alertness and mental focus, caffeine consumption causes vessel constriction, also recognized as vasoconstriction. Vinpocetine counteracts the vasoconstriction of caffeine causing blood vessels to dilate in order that additional blood will flow through them towards the brain.

Considerations

As an herbal-derived nootropic, Vinpocetine is really one of the safest supplements you can take. The side effects of vinpocetine may generally feel like you have got simply drunk a weak cup of coffee, but for the most part negative symptoms aren’t experienced. It is suggested to avoid using vinpocetine throughout pregnancy and lactation due to lack of clinical studies.

Recommendations

Most clinical studies used vinpocetine 10 mg 3 times daily and this can be by and large enough for many users to attain their desired effects. Vinpocetine should be taken orally daily. For relieving thinking and/or memory disorders, as well as Alzheimer’s disease, it is suggested that the daily dose is 5-10 mg 3 times.

Sources