Tianeptine, also known with some other brand names as Stablon, Coaxil, Tatinol, Tianeurax, Salymbra, is a water-soluble compound that has nootropic tendencies and is primarily used in the treatment of major depressive disorder.  Though Tianeptine is chemically a tricyclic antidepressant (TCA), it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity. Tianeptine was discovered and patented by The French Society of Medical Research in the 1960s and now currently being used to reduce depression throughout the world.[1]
However, besides being used as a supplement for reducing depression, Tianeptine is a powerful anxiolytic that can help patients with Parkinson’s disease [2] and also in the treatment of post-traumatic stress disorder.[3] Now tianeptine is also taken as a cognitive enhancer by many users and it is reported to produce sensations of wellbeing, optimizing and mental clarity.


Tianeptine supplement is most popularly known for its quality to reduce anxiety and depression. But, as a nootropic agent, it has a variety of effects on the human health including motivation enhancement, anxiety suppression, cognitive euphoria, focus enhancement, innovation, and cognitive fatigue, etc. Most of all, it effectively improves cognitive functions in depressed patients.[4]
The most proven health benefits of tianeptine include –

  • Improve depressive symptoms[10]
  • Enhance cognitive functions
  • Reduce anxiety, stress, and PTSD[11]
  • Improve memory, learning and mood[12]
  • Increase focus, motivation and attention
  • Help people who have Parkinson’s disease[13]
  • Help people who have Alzheimer’s disease[14]
  • Act as anti-inflammatory[15]
  • Reduce neuropathic pain[16]
  • Reduce asthma[17]

Tianeptine enhances the synaptic uptake of serotonin with minimal effects on norepinephrine and dopamine uptake. Tianeptine is a generally well-tolerated medication which, like the SSRIs, has both antidepressant and anxiolytic activity. Preclinical work suggests that tianeptine has neuroprotective effects against stress-induced dendritic atrophy in the hippocampus, and has neurogenic actions  and might engender these effects via modulation of glutamate neurotransmission.[5]
Tianeptine is quite effective in some other physical functions such as it can block panic attacks from occurring.[6] It also has positive effects on treating pain associated with fibromyalgia, treatment of depression in men with erectile dysfunction [7], and it is also mild effective for ADHD. [8].

How it works

Tianeptine supplement works in several ways and so its mechanisms of actions are also different. Tianeptine in some way enhances the extracellular concentrations of Dopamine in selected brain and neuron pathways and affects in boosting mood. Tianeptine works by modulating different types of Dopamine receptors within the brain. There also appears to be some effect on Glutamate receptors, which has an essential part to play in reversing impaired neuroplasticity that is often associated with stress. Since it modulates AMPA receptors for Glutamate, this technically qualifies Tianeptine as an Ampakine.
Tianeptine is also an SSRE (selective serotonin reuptake enhancer) that causes Serotonin which is released from your neurons to be reabsorbed. Neurotransmitters are stored in tiny vesicles within the synapses of your neurons until they are released. When a neuron fires and release is triggered, the neurotransmitter departs the vesicle and enters the synaptic gap where it binds to the receptors of other neurons. And when this action ceases, the neurotransmitters are then destroyed by an enzyme or taken up again by the releasing neuron. Tianeptine increases Serotonin reuptake in order that it is removed quickly from the synaptic gap and stored again in its neuronal vesicles.[9]


Tianeptine side effects are considered mild and tolerable compared to most other antidepressants. Some mild side effects may include – headache, dizziness, insomnia / night terrors, drowsiness, dry mouth, nausea, constipation.
But the side effects of tianeptine completely depend on the individual and personal biochemistry. So consult your doctor for better suggestions.


The tianeptine dosage usually comes in a 12.5 mg formulation. The generally recommended dose could be to take a single pill or tablet 2 or 3 times a day and it is only for the normal weight individual. But there are some who take upto 25 mg a day.
It is suggested that if you are a new user, begin with a smaller dose, perhaps cutting a tablet in half and taking this in the morning and then again at night. Only increase the dosage level once you have become familiar with its effects. However, only use this supplement under the consultation and guidance of a qualified physician who knows your medical history.


Where to Buy

buy nootropics at amazon

Please use our link to make your amazon purchases as we use the commissions to help fund our research projects which in the end help you and the rest of the uplifted community. We do not have any affiliation with the company providing the product that we are referring you to. Our decision to find the best on Amazon is completely based on our scientific testing methods here at Nootripure Laboratories.

Here at Nootripure Laboratories we like to test supplements for potency as part of our market research and competitor analysis. We already did the research so we figured we would share with you the best products for each supplement. It is sold as a research chemical for you to do non-clinical (not ingested) research for legal reasons. The purity is pharmaceutical grade meaning it is about the same quality as anything you would find in the hospital. Tianeptine is difficult to find on the internet, but we found one store that has it available on Amazon and you can buy it here.