Theacrine

Background

Theacrine, also known as 1,3,7,9-tetramethyluric acid, is structurally similar to caffeine and it is  well-known for its powerful ability for acting as a stimulant. Theacrine is a purine alkaloid found in a traditional Chinese tea known as kudingcha (Camellia Assamica variant Kucha), and it’s commonly known as Kucha. [1][2] Theacrine is a powerful nootropic compound and has energy increasing effects similar to caffeine – but with less tolerance, i.e., without the jitters, crash, and habituation that often accompany caffeine. [3]

Benefits

Theacrine has shown primary potential in recent studies. It appears to offer effects similar to caffeine – but with less tolerance. The nootropic compound in Theacrine has a great role in enhancing cognitive performance in people. Theacrine is both a physical and mental stimulant. It is actually able to raise dopamine levels and reduce stress and anxiety. It can provoke Thermogenesis   and facilitate fat burning, and also reduce inflammation throughout the body. Theacrine has mood enhancing effect. Theacrine does not create the sense of euphoria, but sense of improved energy, focus, mood and motivation.
The most common health benefits of Theacrine include:

  • Enhances cognitive performance [5]
  • Increases energy, focus, concentration and motivation [6]
  • Improves mood [7]
  • May help with depression [8]
  • Promotes sleep [9]
  • Reduces inflammation [10]
  • Decreases cholesterol [11]
  • Reduces stress [12]
  • Improves athletic performance [13]

Theacrine is also used for aging, the common cold, fatigue, and mental performance. Theacrine is also added to pre-workoutsupplements promoted for improving athletic performance. [14]
A questionnaire survey of subjective feelings related to energy and mood found that Theacrine fared favorably compared to caffeine alone and placebo.

How it works

Researchers have resolved that theacrine primarily works in two ways: it facilitates adenosinergic neurotransmission and dopaminergic neurotransmission. That is, theacrine increases physical energy by causing adenosine signaling changes similar to caffeine. It also performs as a dopamine antagonist by causing dopaminergic signaling, which increases physical energy even further. In plain language, theacrine enhances both physical and mental energy in your body by raising levels of certain neurotransmitters – like dopamine.
Generally our figures are equipped with numerous potent antioxidant defense mechanisms, including our body’s most powerful antioxidant and detoxification agent – glutathione so that they combat the potential hazards of excessive oxidation. Glutathione, together with several other antioxidant enzymes, is produced in the liver.
Researches show that following seven days of Theacrine supplementation subjects proved elevated levels of glutathione inside cells, which suggest that the liver receives a secondary benefit from supplementation. [4]

Considerations

One of the most popular benefits of theacrine is its few side effects. If you avoid caffeine because of the jitters, irritability, tolerance buildup, or other unwanted effects, then theacrine might be a welcome change.
Because of insufficient reliable information about the safety of taking theacrine if you are pregnant or breast feeding, it is wise to stay on the safe side and avoid use.

Recommendations

The recommended dosage of theacrine is between 50mg to 300mg. If you want to take theacrine to increase your energy, then start with doses of 50mg before hitting higher until you feel comfortable with your energy boost.

Sources