THC

Background

THC, or tetrahydrocannabinol,(also known as Dronabinol), is the most important psychoactive cannabinoid compound in cannabis and also the substance responsible for most of marijuana’s psychological effects. ‘Unlike CBD which is non-psychoactive, THC attaches cannabinoid receptors and activates them affecting a person’s memory, pleasure, movements, thinking, concentration, coordination, and sensory and time perception, according to NIDA. An Israeli chemist by the name of Raphael Mechoulam was the first man to isolate delta9-Tetrahydrocannabinol (THC) in the early 1960s.[1]

Benefits

THC, or tetrahydrocannabinol, the most recognized ingredient in cannabis, has a number of medical benefits though compounds like cannabidiol (CBD) have started to gain favor due to their lack of psychoactivity. Like nootropics, THC, or, Delta-9-tetrahydrocannabinolI in cannabis has a number of positive benefits that include –

  • Enhances mood [6]
  • Increases appetite [7]
  • Has been reported to lower levels of anxiety, stress, and depression [8]
  • Reduces nausea and vomiting [9]
  • People report it improves focus and fewer distractions
  • Improves reaction times, more creative thought, greater verbal fluency, and better calculative complexity [10]
  • Helps people who have Alzheimer’s Disease [11]
  • Helps with neuropathic pain [12]
  • Helps with multiple sclerosis [13]
  • Helps people who have Parkinson’s Disease [14]
  • Helps people who are fighting cancer [15]
  • Helps with Crohn’s and inflammatory bowel diseases [16]
  • Helps with PTSD [17]
  • Acts as a powerful antioxidant [18]

It is best known for causing the high that you get from using marijuana. Some of the most common uses of medical marijuana is for pain relief, post-traumatic stress disorder (PTSD), sleep aid, reducing nausea, relieving asthma, and nausea and vomiting in cancer patients. A different benefit of THC is that it is helpful to relieve eye pressure in patients with glaucoma.[2][3] And in some rehabilitation clinics they use marijuana as an exit drug from more harsh drugs such as methamphetamine or heroine.

How it works

THC (delta-9-tetrahydrocannabinol) and other chemicals enter your body with your smoking cannabis or marijuana. If cannabis or it’s oils are ingested, delta-9-THC is broken down into it’s metabolites THCV and delta-8-THC. These are completely different drugs with similar effects. This is why people report that edibles may be more intense or hallucinogenic compared to inhalation.
THC, or, delta(9)-Tetrahydrocannabinol is the principal source of the pharmacological effects caused by the consumption of cannabis, both the marijuana-like action and the medicinal benefits of the plant. However, its acid metabolite THC-COOH, the non-psychotropic cannabidiol (CBD), several cannabinoid analogues and newly discovered modulators of the endogenous cannabinoid system are also promising candidates for clinical research and therapeutic uses. Cannabinoids exert many effects through activation of G-protein-coupled cannabinoid receptors in the brain and peripheral tissues. Additionally, there is evidence for non-receptor-dependent mechanisms.[4]
Since THC is a highly lipophilic compound, it is readily distributed into tissues from blood circulation. THC concentrations in brain reach a maximum, about three to six times higher than in plasma, within 30 minutes (the first sampling time after drug administration) after a single intravenous (IV) dose of THC in animals. THC brain concentrations roughly parallel the plasma concentrations. This indicates that there is no barrier for the partition of THC into brain and that an equilibrium between the brain and plasma is quickly reached.[4] However, because it is lipophilic, it makes it difficult for the body to absorb. Modern technologies are seeking to solve this problem as the industry continues to rapidly grow.

Considerations

According to the National Institute on Drug Abuse, most people who use THC experience a tranquil and calming effect, drowsiness, and a lack of motivation. And long term effects are – developmental problems in adolescents and young adults, memory loss and other cognitive impairments and smoking marijuana for long time can cause eating disorders, sleeping disorders, lung infections or lung diseases.[5]

Recommendations

You have to be cautious enough because the effects of smoking cannabis can be felt almost instantly; dosage control is relatively easy compared to other consumption methods. The quarter gram joint is best suited for light smokers, while the 1 gram joint will suffice for heavy smokers and larger groups.
Again, because the cannabinoids in edibles are absorbed through the gastrointestinal (GI) tract, the onset time is delayed (30 to 90+ minutes) relative to other consumption methods. For new consumers, doctors usually recommend to start with 1-5mg of THC. When you become more familiar with your edible tolerance, it will be easier to adjust dosage. For occasional consumers, 5-10mg of THC is commonly recommended.

Our Involvement

We don’t include THC in any of our distributed products, however we conduct research on individuals who do consume cannabis in search for better understanding the cause of possible side effects and also nootropic benefits. We do include cannabinoids in every product we produce because of their unmatched healing and nootropic effects, but none of them are sourced from the cannabis plant and contain absolutely no THC. To learn more about our research, please visit nootripure.org.

Sources