The Best Racetam for Nootropic Supplement

Scientific Facts about racetam

Racetams are a class of nootropics that are most commonly known as a cognitive enhancing supplement that all share a similar chemical structure with a “pyrrolidone nucleus”. Almost all racetams have a 2-pyrrolidone nucleus made up of oxygen, nitrogen, and hydrogen. Actually, racetams are well-known for their influence in improving memory, learning, mood, focus, and energy levels along with positively affecting most of the basic components of brain health. Most of the racetams work by stimulating receptors for the neurotransmitter acetylcholine whereas some increase uptake of glutamate by activating AMPA and NMDA receptors. Very few components of any nootropic stack are as powerful as racetams which are really an excellent supplement for an individual who really wants to improve the cognitive function and health of their brain.

What is the First racetam?

It’s true that racetams are an interesting set of nootropics. There are a lot of racetams in today’s market. But the first racetam synthesized by Romanian scientist, Dr. Corneliu Giurgea, is now one of the most commonly searched nootropic compounds in the world. Yes, it’s Piracetam. It is an original drug and it has been showing promise for neurodegenerative diseases like dementia and Alzheimer’s disease. In 1964, many other great scientists challenged Giurgea’s discovery and created various other racetams that all have similar structures, but varied psychoactive effects within the brain.

Which ones are the most popular and effective Racetams as a Nootropic supplement?

Although piracetam was fascinating upon its unique synthesis, many new racetams have been developed over the past 53 years by great biochemists, pharmacologists, and researchers. Each of the racetams contains the pyrrolidine nucleus. However, the differences in the molecular structure consent for huge differences in the effects of each component. Currently, we’re going to sketch the differences among the most popular and effective racetams so that you can decide for yourself which one might be the best for you. The best Racetams that commonly used as a nootropic supplement.


Piracetam (also known as nootropil) is known as the parent compound of the racetam family of nootropic supplements. In fact, this is the first racetam to be synthesized by Dr. Giurega in 1964and the term ‘nootropic’ was born. For whatsoever grounds, this supplement works wonders for individuals with memory loss and also improves the memory of ordinary students and high-performance individuals of all ages. There are over 120 published papers and more than 53 years of research on the subject which make this racetam most popular and well-respected within the class of drugs.
Actually, piracetam works by stimulating the neurotransmitter Acetylcholine receptor system that causes more of this neurotransmitter to be released into the brain. According to a meta-analysis of human studies, piracetam helps improve general cognition when supplemented by individuals in a state of cognitive declines, such as the kind that comes with aging, as well as provides a mild boost to brain function.[1]
Dosage: The recommended dosage for piracetam can be between 1 and 3 grams, up to 3 times per day.


Aniracetam is probably the second most well-studied racetam and a popular choice among nootropic users for its ability to enhance cognition while reducing anxiety and boosting mood. Aniracetam was developed as a more powerful analog of the nootropic drug Piracetam and is said to be 3-6 times more effective than Piracetam and has greater oral bioavailability, in part because it is fat-soluble. Many anecdotal reports claim that this drug is associated with increased creativity, memory, and learning ability. Aniracetam has also been used to improve cognitive performance and improve mood and motor performance in patients with stroke and Alzheimer’s disease.[2]
Dosage: The recommended dosage for Aniracetam can be between 600 and 3000 mg per day. Moreover, it is wise to supplement with choline when using this racetam to avoid headaches during your usage.


Oxiracetam, a powerful nootropic, is a synthetic molecule derived from piracetam, but structurally it is different from piracetam for a single hydroxyl group, and 5 times more advanced in potency than piracetam as well as aniracetam. Oxiracetam appears to have the most potential for neuroprotection and recovery from neurological trauma. It also appears to enhance long-term potentiation (LTP) memory formation.[3]
Oxiracetam supplementing can cause you to experience improved spatial memory and learning. It is seen that oxiracetam seems to be better than piracetam in this act.[4] Its effects include higher levels of choline acetylcholinetranferase – a neuro-enzyme that is responsible for the creation of the acetylcholine neurotransmitter.
Dosage: The recommended oxiracetam daily dose can be between 750 – 1,600 mg per day. For studying or doing any sort of mentally exhausting work, many users take oxiracetam doses every 6 to 8 hours.


Nefiracetam is one of the lesser-known nootropic supplements from the racetam family even though there are enough studies for this supplement on its efficacy for neuroprotection and cognitive enhancement. It is originally derived from the parent molecule piracetam but it shares most structurally similarities with aniracetam. Both nefiracetam and aniracetam are fat-soluble racetam drugs for the purpose of memory enhancement or the improvement of cognitive function. Nefiracetam seems to be able to enhance memory formation when taken daily over a lengthy period of time (say 7 days or longer).[5]
One important thing to note is that piracetam, aniracetam, and oxiracetam are all classified as positive AMPA modulators, where nefiracetam is a bit different.
Dosage: The recommended daily dose of nefiracetam can be between 500 mg and 1800 mg for a person of average weight.


Phenylpiracetam is considered one of the most popular and successful nootropic supplements in today’s racetam family. It’s also known as Phenotropil or Carphedon and is derived from Piracetam in which the only modification is the addition of a phenyl group to its structure. However, this modification has caused a huge improvement in the efficacy of the drug.[6]
Phenylpiracetam has nootropic properties and can have a pronounced stimulatory effect on motor responses and improve physical performance. Actually, it is reported to be more neuroprotective than piracetam and possesses psychostimulatory properties. Phenylpiracetam is also very effective in improving cognitive function. Though phenylpiracetam has previously been used by the athletes, it is now included in the WADA (Olympics) list of prohibited during sports for its psychostimulatory and cold resistance properties.[6][7]
Dosage: Phenylpiracetam is much more effective than many other racetams, and thus you only need about 100 mg to feel the effects. There is an unfortunate characteristic of phenylpiracetam supplement, and it is quick tolerance. In order to avoid tolerance, it is best to take 200 mg to 300 mg a day only 1 to 2 times per week.


Coluracetam (MKC-231) is a synthetic racetam drug and structurally similar to piracetam, but it has a different mechanism of action altogether. This nootropic supplement seems to interact with a process known as high-affinity choline uptake (HACU), which is the rate-limiting step of drawing choline into a neuron for synthesis into the neurotransmitter acetylcholine. Enhanced HACU rate seems to increase the activity of cholinergic neurons, and as a result, it is the desired target for cognitive enhancement.[8]
Dosage: The recommended daily dose can be between 2.5 to 3.0 mg per kilogram of body weight. If you are of average weight, this should work out to approximately 200 mg per day of Coluracetam.


Pramiracetam is another racetam molecule that was primarily synthesized from piracetam. It is said to be 30 times more potent than piracetam. It is fat-soluble and more bio-available and considered the strongest of the racetam nootropics as well as longer-lasting. Pramiracetam is well-known for cognitive enhancement and for increasing mental energy levels and improving memory and neuroplasticity to make it easier for you to learn.
It may be able to enhance high-affinity choline uptake (HACU). It is similar to piracetam and other racetams in the sense that its mechanisms seem dependent on the adrenal glands and some peripheral effects,
Dosage: The recommended daily dose of Pramiracetam can be between 100 – 1,200 mg in a 24-hour period.


Fasoracetam is one of the newest and unique racetam supplements. This nootropic drug is associated with numerous health benefits, including focus and neuroprotection. A study conducted on attention deficit hyperactivity disorder (ADHD) suggests that fasoracetam may be helpful for ADHD patients.[9]
In fact, fasoracetam is a great supplement as it has the ability to affect both memory formation and learning (as is the case with the entire racetam line), but also increases stimulation and focus. It is also called a study pill, as students take it for better performance.
Dosage: Being more potent, you perhaps don’t need to take more than 50 mg a day.

 What about Noopept?

Noopept is a popular nootropic compound and an identical way of action to racetams, but it is thought to probably be one thousand times stronger than Piracetam. Though it has similar impacts on the brain, it is structurally different from racetams.[10]
Noopept is even compared to piracetam in many scientific literatures. But, unlike racetam it does not have a 2-oxopyrollidine skeleton. So, it can’t be a racetam.[/vc_column_text][vc_custom_heading text=”Choose Your Best Racetam” font_container=”tag:p|font_size:50|text_align:left|color:%23c1c1c1|line_height:1.4″ google_fonts=”font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal” css=”.vc_custom_1534502683599{margin-top: 50px !important;margin-bottom: 30px !important;}”][vc_column_text]The racetam family of nootropics are considered the first nootropics to be discovered, and the first molecule called piracetam was created by Dr. Corneliu Giurgea. Since then, many other effective racetams have been discovered. And we have already discussed the most popular and effective racetams above. But which one is the best for you?
Before deciding which one is best for you, it’s necessary to consider a distinction among many of the racetams. They are generally considered safe, and there are some that are more well-researched than others. You will find a lot of scientific literature about piracetam and aniracetam. On the other hand, there are some other racetams like phenylpiracetam or fasoracetam which are considered the best racetam within some nootropic communities, but they lack enough scientific literature to back up that claim.
From my personal experience and many other users’ experiences, it’s observed that phenylpiracetam seems to be very pronounced. The quality is also exceptional. It is truly a powerful nootropic. It is stimulating, but in a different way than caffeine. But, if you are a beginner to take phenylpiracetam supplement, you are suggested to choose whatever dosage sounds best for you. But remember, start at low doses.