PQQ is associated with a wide range of benefits for the brain and body, for instance stimulating mitochondria biogenesis, production of nerve growth factors, and antioxidant activity.
Actually, mitochondria in your body can be compared to the batteries that supply power to your body. When you age, the performance of mitochondria that you have in your cells decreases, and, as a result, it reduces your health and longevity. PQQ is a composite often found in mitochondrial support supplements that increases the formation of new mitochondria and enhances cellular energy production.
The most common health benefits of PQQ include:

• Enhances cognitive function [2]
• Relieves inflammation [3]
• Reduces oxidative stress [4]
• May extend longevity [5]
• Promotes mitochondrial function [6]
• Decreases cholesterol [7]
• Improves sleep [8]
• Improves learning ability and memory function [9]
• Increases nerve growth factors (NGF) [10]
• It May help people who have Parkinson’s and Alzheimer’s diseases [11]
• May protect the heart against stroke [12]
• Possesses potent neuroprotective effects [13]
• May help fight cancer [14]
• Improves immune function [15]

Studies show that PQQ helps reduce stress, fatigue and improves quality of life and sleep. The study finds improved quality of life, appetite, sleep, obsession and pain. It shows significant improvement in sleepiness at awakening, sleep onset and maintenance, and sleep duration.

PQQ has a diversified mechanism of action. Studies demonstrate the unique ability of PQQ to stimulate the formation of new mitochondria and improve the function of existing mitochondria. Studies on animals show that PQQ activated the cAMP response element-binding protein (CREB), and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha). This pathway is known to regulate mitochondrial biogenesis.[17]
PQQ promotes the growth of new nerve cells through stimulation of nerve growth factor (NGF) in brain cells. Actually, PQQ demonstrate that it is far superior to other molecules that aim at stimulating nerve growth factor in cultures of brain cells. PQQ is very effective in fighting oxidative damage and, as a result, helps protect you from neurodegenerative diseases like Parkinson’s disease.
A study showed PQQ’s neuroprotective effects that PQQ led to significantly improved neurobehavioral scores after the stroke. The provided data indicate that PQQ may be a useful neuroprotectant in stroke therapy. So, it can be said that PQQ can be given to stroke patients in the emergency room to reduce paralyzing brain damage.