Pterostilbene

Background

Pterostilbene, also known as trans-3, 5-dimethoxy-4-hydroxystilbene, 3, 5-dimethoxy-4-hydroxystilbene, is a powerful antioxidant that can help you by improving brain, heart, and immune system function. It is, actually, a stilbene molecule and dimethylated derivative of Resveratrol, an antioxidant that helps fight free radical damageand slows down the aging process. Pterostilbene can be obtained from foods such as almonds, grape leaves and vines, and especially blueberries, but in a very scanty amount. Pterostilbene supplement helps improve cognition, maintain blood sugar, and increase insulin sensitivity.[1]

Benefits

Pterostilbene is a natural dietary compound and considered the primary antioxidant component of blueberries. It is structurally similar to resveratrol, a compound found in red wine that has comparable antioxidant, anti-inflammatory, and anticarcinogenic properties. The supplement may have numerous protective and therapeutic properties in a vast range of human diseases that include neurological, cardiovascular, metabolic, and hematologic disorders. As a nootropic, pterostilbene is used to promote cognitive health and offers a variety of neuroprotective benefits. In studies, Pterostilbene has been shown to be a potent anticancer agent in several malignancies.[2]
The common health benefits of Pterostilbene include:

  • May reduce oxidative stress [3]
  • May have an effect on some cancers [4]
  • Supports cognitive health [5]
  • May have an effect on Alzheimer’s disease (AD) [6]
  • May help reduce risk for cardiovascular and metabolic disorders [7]
  • May reduce inflammation [8]
  • Boosts the immune system [9]
  • Helps maintain blood pressure [10]
  • Helps maintain blood sugar levels [11]
  • May lower cholesterol [12]
  • Helps improve metabolism [13]
  • May help improve learning and memory [14]
  • Has an effect on anxiety [15]

Pterostilbene is believed to be very effective when combined with Resveratrol. And it is particularly true when we consider the effects of normal calorie restriction. This supplement is able to lessen blood sugar levels and help reduce elevated cholesterol levels. Pterostilbene is considered to be anti-inflammatory and it also works as an anti-oxidant. In plants, it also shows anti-fungal and anti-viral activities. However, pterostilbene displays increased bioavailability because of the presence of 2 methoxy groups that cause it to exhibit increased lipophilic and oral absorption.

How it works

Pterostilbene, a structural analogue of resveratrol, is a stilbene found in several types of blueberries such as rabbiteye blueberries and also in unripe Pinot noir grapes. Pterostilbene has a wide range of health-beneficial effects. Being a stilbene compound, Pterostilbene acts as an inducer of multiple cell-death pathways such as apoptosis, cell cycle arrest, and autophagy for chemopreventive and chemotherapeutic agents in several types of cancer cells.[16]
Pterostilbene also increases dopamine levels. Numerous studies show that neurodegeneration is caused by oxidative stress and anti-oxidants can discontinue and even reverse damage to neurons. Dopamine, an important neurotransmitter, is increased then. Actually, Pterostilbene is a powerful antioxidant. Studies demonstrated that Pterostilbene is very effective in improving cognitive function. Increased Pterostilbene can cause more dopamine release, and, as a result, there is an increase in working memory correlated with pterostilbene levels in the hippocampus.[17]

Considerations

Pterostilbene is considered safe and a compound without any side effects. It is because there is not much information regarding side effects of this supplement. It seems that there are a few people using pterostilbene online in communities like Reddit and Longecity without any side effects. But this doesn’t mean that it will be the same for everyone. A study shows that high dosages of pterostilbene may cause LDL cholesterol to increase.[18]
However, it is still wise to only start with a low dose and work up from there, but it is incredibly safe and there is low risk of any negative outcomes.

Recommendations

There is no a standard dosage for Pterostilbene that suits for all remedies. The dosage depends highly on the desired effect. But it is true that even low dosages in supplement form (extract, powder, etc.) have benefits when it comes to fighting oxidative stress and disease. In some human studies, usually 200 to 700 mg or less are taken. Even if your dosage is as little as 10 mg, it may offer you some benefits. If your doctor doesn’t advise taking a different pterostilbene dosage, you can take it depending on your body weights, such as if you are under or about 150 pounds, take 215–430 mg per day. For 200 pounds of your body weight, take 290–580 mg per day, and for over 250 pounds of your bodyweight, take between 365–730 mg daily.
You are advised to consult your physician or healthcare provider first if you want to increase your dosage.

Sources