Phenethylamine (PEA), also known as β-phenylethylamine, is a trace amine found in tiny amounts in the brain and is considered an influencer of many of the ‘happy hormones’ such as dopamine and serotonin.[1] Phenethylamine stimulates the body to make certain chemicals that play a role in depression and other psychiatric conditions. As a nootropic, phenethylamine has the cognitive enhancement and mood boosting effects. Phenethylamine is taken for improving athletic performance, depression, weight loss, mood and attention.[2] Phenethylamine supplement is also well-known for its important roles in the process of obsession and sexual drive.


With its nootropic properties, Phenethylamine (PEA) is associated with a lot of health benefits in both physically and mentally. The main benefits of this supplement are considered the mood enhancement and an overall feeling of wellbeing. As there is an increase of several neurotransmitters, many users may experience great something in them. Another neurotransmitter called Acetylcholine in Phenylethylamine is usually thought to play a key role in a number of cognitive processes such as memory formation, learning capacity, speed of recall, and might even lead to a lengthening of attention spans, improved mental clarity, focus, and concentration.
The common health benefits of Phenethylamine include:

  • Reduces depression [3]
  • Promotes mood [4]
  • Improves alertness [5]
  • May improve the symptoms of schizophrenia [6]
  • Improves brain function [7]
  • Helps with attention deficit hyperactivity disorder (ADHD) [8]
  • Improves weight loss [9]
  • Increases sexual drive [10]
  • Enhances memory [11]
  • Improves learning [12]
  • Improves mental health [13]
  • Reduces anxiety [14]
  • Has stimulant effects [15]

There is also some evidence to suggest that phenylethylamine helps in alcohol (and stimulant) addiction.[16]

How it works

Like most other nootropics, Phenylethylamine almost is with the similar mechanism of action. Meaning that, it is readily absorbed into the bloodstream (ordinarily through the intestinal system) and then crosses the blood-brain barrier.
Phenylethylamine activates a receptor called TAAR-1 (trace amine-associated receptors) in the brain to generate the release of neurotransmitters which send chemical signals to different targets in the body causing various responses such as happy, sad, scared, and awake. With the activation of TAAR – 1, Phenethylamine increases the release of neurotransmitters like serotonin, epinephrine, dopamine, and norepinephrine from neurons, which are extremely important to proper mood, cognitive function, and mental well-being. Besides helping increase the production and/or release of these powerful brain chemicals, it works to block the action of their transmitters (chemicals within the brain that work to lessen the concentration of these neurotransmitters). So, there are higher levels of stimulation for your Dopamine and Norepinephrine synaptic receptors.


Unlike other nootropics, Phenylethylamine has some mild adverse effects. The side effects include things like headaches, heart burn, nausea, constipation, and perhaps some insomnia, and dizziness. As soon as you face any of these side effects, reduce the dosage or even stop using it until you get back to complete well-being. However, consult your doctor to know whether Phenylethylamine is suitable for you.


The commonly recommended daily dosage range for Phenylethylamine (PEA) supplement is between 250 and 1,000 mg per day. If you are a new user of PEA, you should start with the lowest dose and can increase if its effects adjust with your body. Consult your physician or healthcare provider for fixing your appropriate dose.
You should not use Phenylethylamine if you are also taking other medications such as MAO-Is for the treatment of depression.