Phenibut (β-Phenyl-γ-aminobutyric acid) is a derivative of the natural molecule that regulates communication between neurons in our brain GABA. It usually acts as an inhibitory neurochemical, meaning that is slows down neurological processing. It’s practically a similar structure of baclofen (lacking only a chlorine atom within the para-position of the phenyl group) and contains phenethylamine in its structure. At first Phenibut was developed in Russia at the USSR Academy of Medical Sciences in Nineteen Sixties and is now widely used in Russia to relieve tension, anxiety, and fear, to improve sleep in psychosomatic or neurotic patients. It has anxiolytic and nootropic (cognition enhancing) effects.[1]


Phenibut is neuroprotective and a nootropic supplement like the neurotransmitter GABA that has the power to lessen anxiety and alternative psychological symptoms, and supply a sense of calmness. Several nootropics have many good points, and Phenibut is not any exception.
The common health benefits of Phenibut include:

  • Improves cognition [2]
  • People often use to reduce stress, anxiety and depression [3]
  • Protects heart health [4]
  • Increases immunity [5]
  • Helps with respiratory health [6]
  • Promotes sleep [7]
  • Reduces signs of fatigue [8]
  • Has been used in the past to help with post-traumatic stress disorder (PTSD) [9]
  • Improves memory, learning, and thinking [10]

People largely use Phenibut due to its wonderful effects in reducing stress and anxiety. At moderate doses, Phenibut is in a position to extend the user’s mood, and it permits the user to feel more sociable and stress-free. It’s a good substance for individuals living a fast, stressful life who would like a bit time to chill out and relax.  Individuals also use Phenibut to assist falling asleep easier and to help in an exceedingly healthy, full night’s sleep.

How it works

Phenibut’s mode of action is however to be unconcealed. Although, some literature shows that when it’s able to cross the blood brain barrier, it in real time communicates and stimulates somatic cell receptors, significantly GABA-A and GABA-B receptors. This mode of action is comparable to how alcohol is in a position to stimulate these receptors to lessen feelings of stress and anxiety while promote sedation, muscle relaxation and reduction of inhibitions. This ability sets Phenibut apart from other nootropic agents in that it does not have a stimulating effect.
Besides, it also has the capacity to enhance one’s cognitive organization through decreasing “over thinking.” Despite restricted studies conducted concerning Phenibut, there’s some proof proving that it’s going to facilitate in increasing the cognitive performance of people who are supplementing with this compound. Studies show that it’s going to be able to exhibit this improvement through enhancing the communication between the right and left brain hemispheres resulting in creativity and higher problems solving talents.


Though Phenibut is usually safe for human consumption, you will experience some side effects significantly if you’re taking it with alcohol that causes giddiness, light-headedness, indigestion, nausea, tiredness and headaches. If you’re on drugs or benzodiazepines, please seek advice from your doctor before using Phenibut since Phenibut affects a similar component of the brain as alcohol and benzodiazepines, and will interfere with certain prescription medications.


The counseled dose for Phenibut is 250 mg to 750 mg. You may take over this range; however, you must not exceed one g daily. We conjointly suggest that you simply begin with a lower dose to judge the individual effects of Phenibut to your body.