Oxiracetam

Background

Oxiracetam, a powerful nootropic, belongs to the racetam family and is very mild stimulant. Though it is a synthetic molecule derived from piracetam, structurally it is different from piracetam for a single hydroxyl group, and 5 times more advanced in potency than piracetam. Similar to all other racetams, it is a synthetic molecule not found in food sources or in nature. The nootropic supplement Oxiracetam has been well-known as a smart drug to promote cognitive function, enhance memory, learning and mental energy.[1]

Benefits

Among the popular nootropics, Oxiracetam is one of them which is also well known and highly regarded for its great cognitive enhancement properties and mild stimulant capability. However, when it is used in cognitive decline, it is somewhat equivalent in potency to Alpha-GPC and seems to be slightly more potent than piracetam. This supplement is exceptional of its own as well as when in stack or combination with other supplements.  Some wonderful health benefits of Oxiracetam are –

  • Improves memory, learning and recall [4][9]
  • Increases attention, focus, concentration and motivation [5]
  • Improves physical and mental health [6]
  • People report it enhances mind and creativity
  • Improves the cognitive performance [7]
  • Promotes sleep [8]
  • Helps with Alzheimer’s disease and dementia [10]
  • People also report it helps with age-related cognitive decline, autism, ADHD/ADD and schizophrenia

 Although most of the benefits of Oxiracetam are seen through cognitive functioning, it is also known to act as a neuroprotective. It protects the brain, keeps your neurons remain healthy. It also works as an antioxidant that helps the brain send out various toxins. Some research has also found that Oxiracetam may potentially turn around the damage that is seen relating to alcohol abuse.

How it works

Oxiracetam appears to affect the cholinergic system and increases neurotransmission in the hippocampal region of the brain. It is observed that oxiracteam at doses of 100 and 300 mg/kg i.p., increases acetylcholine (ACh) utilization, but not steady state ACh levels. Moreover, repeated daily administration of 100 mg/kg of Oxiracetam increases high-affinity choline uptake (HACU) in the rat hippocampus by 31%.
A similar increase in HACU is also observed after a one-time dose of 300 mg/kg i.p.; even three hours after the administered dose, HACU rate remains 40% higher. These observations were used to hypothesize that “Oxiracetam enhances the activity of the septohippocampal cholinergic pathways, and to a lesser extent the, of the cortical cholinergic network.”[2]
Oxiracetam is also observed to increase neurotransmission in the CA1 rat hippocampal region. The enduring increase in neurotransmission shared characteristics with long-term potentiation (LTP), which happens primarily in the hippocampus and may be a physiological site for learning and memory. [3]

Considerations

Oxiracetam is well tolerable and side effects may be possible only when too high dosages are taken. Some common side effects like other nootropics can be headache, anxiety, nervousness, diarrhea, and nausea. But these side effects are minor and easily avoidable.

Recommendations

The daily dosage recommendations for Oxiracetam can be ranging from 400 mg to as much as 2400 mg, taken 2 to 3 times a day. Though studies consuming higher cumulative daily dosages have shown no adverse effects, it is always wise to begin with the lowest possible effective dosage and gradually increase as needed.
Oxiracetam is water soluble and mixes readily, so it can be taken in either capsule or powder form as well as taken with or without food.

Sources