Oleamide

What is Oleamide

Oleamide, also known as cerebrodiene, is an amide of the fatty acid called oleic acid. It is an endogenous substance, meaning it occurs naturally in the body of animals and first isolated in human serum in 1989.[1] Oleamide seems to accumulate in the brain and cerebrospinal fluid (CSF) during sleep deprivation and induces sleep. Currently, Oleamide is being studied as a potential therapeutic compound for mood and sleep disorders, and cannabinoid-regulated depression.[2] Oleamide has nootropic properties and is a great calming and relaxing supplement. It reduces stress and anxiety. It has great effect on cognition, learning and memory.[3]

Oleamidde Health benefits

Oleamide is found naturally in all animals and humans. It helps promote sleep. According to the scientists, oleamide helps produce good REM sleep cycles at higher doses. On the other hand, at lower doses, it is a great supplement for calming and relaxing mood. As a nootropic, it is often taken for its effects in reducing stress and anxiety, improving mood, cognition, learning and memory and focus. It is also found by the researchers that oleamide supplement interacts with certain receptors in your brain that may produce psychoactive effects at high doses. The common health benefits of oleamide include:Promotes sleep [4] Protects brain damage [5] Improves cognitive function [6] Improves mood [7] Reduces anxiety levels [8] Reduces stress [9] Has antianxiety and analgesic effects [10] Has relaxing effects [11] Improves learning and memory [12] Increases appetite [13]Again, the distinctive interaction with serotonin receptors shows that Oleamide may have the ability to change your thinking processes – allowing more creative and thinking capacity. However, this has been ensured in animal research, but it’s true that Oleamide in moderate doses has shown an improvement in learning.[14]

How Oleamide works?

Oleamide, a fatty acid amide accumulates selectively in the cerebrospinal fluid of sleep deprived animals. Oleamide has been reported to have effects on a wide range of receptors and neurotransmitter systems especially the centrally acting ones for example, dopamine acetylcholine, serotonin, gamma aminobutyric acid (GABA), cannabinoid and vanilloid among others. This suggests a wide range of central nervous system effects of the compound. Oleamide has antidepressant-like property.[15] Oleamide has been noted to be synthesized in brain slices incubated with both oleic acid and ammonia, which is mediated by enzymes as boiling the brain slices (denaturing enzymes) abolished the synthesis. Oleamide can be degraded into Oleic acid via the membrane enzyme Fatty acid amide hydrolase (FAAH), the same enzyme that metabolites anandamide (arachidonoyl ethanolamide) and bioactives in marijuana.[16]

Consideration and recomendation

Though Oleamide benefits are well-recognized, the side effects of Oleamide supplement have not been fully researched yet, and more human studies are still required. There hasn’t been any mentionable adverse effect noted yet. It is possibly safe to consume. However, some people may experience allergies, in which case you should immediately stop using this supplement.
Oleamide may be associated with a decline in locomotive function, even at medium doses. Users are advised not to attempt to drive or operate heavy machinery when taking this supplement. There is limited research into the safety of this supplement for pregnant and breastfeeding women. Consult your doctor if you have any medical conditions, or you are taking any medication.

Because of the lack of studies on human volunteers into the effects of this supplement, the actual and appropriate dosage is not fully recognized. The recommendation for doses is depending solely on the experience of the users. However, online reviews tend to recommend an Oleamide dosage range which is between 50 – 200 mg, 1 to 3 times daily, depending on the desired effect.
Remember, at a low dose, Oleamide is usually seen to produce anti-stress and mood-lifting effects; whereas larger doses are more effective at reducing the time taken to fall asleep. Consult your doctor or healthcare provider for appropriate doses for you.

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