Nefiracetam

Background

Nefiracetam, also known as DM-9384, N-(2, 6-dimethylphenyl)-2-(2-oxopyrrolidine-1-yl)-acetamide, is a new nootropic compound belonging to the racetam family. Though, originally Nefiracetam was derived from Piracetam, it actually shares more structural similarities to the supplement Aniracetam. Both nefiracetam and aniracetam are fat soluble racetam drugs for the purpose of memory enhancement as well as cognitive enhancement. Therefore, nefiracetam is mostly known as a supplement that enhances cognitive performance and promotes memory formation. It also possesses some beneficial neuroprotective properties. Nefiracetam seems to enhance both GABAergic and cholinergic signaling.[1]

Benefits

Nootropics are mainly used to achieve some type of cognitive enhancement. Nefiracetam is a powerful nootropic. In terms of its chemical structure, Nefiracetam and Aniracetam are quite similar, but their behavior and work are slightly different. Nefiracetam is thought to be able to improve many of the fundamental areas of cognition that may include memory and learning capacity, attention spans, concentration and focus, and perception. Though this new nootropic supplement is used to boost brainpower by increasing activity at certain key areas in the brain, one of its primary benefits is better memory and information retention in the long-term.
The common health benefits of Nefiracetam include:

  • Improves cognitive function [2][4]
  • Increases memory and learning [3]
  • Enhances attention spans, concentration and focus [5]
  • Protects brain neurons [6]
  • Reduces the effect of the seizures [7]
  • Reduces stress, anxiety, and even depression [8]
  • Is highly GABAergic and monoaminergic [9]
  • Helps people who have Alzheimer disease [10]
  • Users report that it helps people who use certain drugs or suffer from rapid aging

Nefiracetam has some exceptional therapeutic benefits. It is well-known for improving cognition and learning abilities. While using this supplement, people experience anti amnesia effects because of the improvement in their cholinergic, GABAergic and monoaminergic neuronal systems. People also use it as an anti-epilepsy drug. If you compare Nefiracetam to Pramiracetam, you will find that it is able to penetrate into the brain better and thus the effects are longer lasting. A potent effect it has in stimulating the AMPA receptors in the brain, which may enhance the attention span and alertness.

How it works

Nefiracetam is considered to be one of the members of oxopyrrolidine acetic acid derivatives such as piracetam, aniracetam, and oxiracetam. A number of studies demonstrate the pharmacological basis of nefiracetam, including an increase in uptake and release of cholinergic and GABAergic neurotransmitters and enhancement of neuronal transmission through activation of neuronal Ca2+ channels and nicotinic acetylcholine receptor. However, the specific mechanisms for anti-amnesic effects of this compound still remain unclear. Numerous experiments show that pretreatment of scopolamine-, benzodiazepine-, and cycloheximide-treated, animals with nefiracetam reveal its anti-amnesic effects in the passive avoidance. Furthermore, this supplement may be able to reveal the long-term-potentiation-like facilitation of the synaptic transmission in the hippocampus, and to improve β-amyloid-induced learning and memory impairments. It is worth mentioning that piracetam-like nootropics may lead to a significant improvement of cognitive functions in patients with Alzheimer’s disease. Thus, nefiracetam has been developed as a therapeutic drug against cognitive disorders in Alzheimer’s disease and/or senile dementia. The therapeutic efficacy of nefiracetam has been under clinical investigation. Nefiracetam may exert a cognition-enhancing effect on ischaemia-induced memory dysfunction and that the effect, if any, may relate to protection of the AC/cAMP/PKA/CREB signal transduction system against ischaemia-induced neuronal damage of the microsphere-embolized animal.[11]

Considerations

Nefiracetam side effects are quite comparable to those of other Racetams. The side effects may include headaches, irritability, nausea, dizziness, fatigue, and stomach issues. However, the headaches associated with this supplement can be easily overcome if you add some Choline supplement like Alpha GPC or Centrophenoxine. When taken in moderate dosage, you may not experience any such adverse effects of Nefiracetam.
Also there appears no serious risk of toxicity when using Nefiracetam at a moderate dose levels. Dosage up to 900 mg per day has been shown as non-toxic and it is safe for any healthy person.
You are advised to consult your healthcare provider before starting any new supplement.

Recommendations

There have already been conducted multiple clinical as well as academic studies on Nefiracetam, all of which used a fairly wide range of doses. One study has recommended that a range from 8 mg per kg of body weight to 30 mg/kg may be an effective dosage level. So, a daily dosage range of Nefiracetam can be between 500 and 1800 mg for a person of average weight. The doses should be split into 2 or 3 equal administrations throughout the day.
Obviously, it should also be mentioned that not everyone will react in the same way. So you may need to do some experimenting until your optimal dosage level is reached. And it is also noted that you should always try and start out with a low dose and then build up when you are comfortable with all the effects. This is particularly important while you are trying a more experimental nootropic like Nefiracetam that has a much lesser history of use. As Nefiracetam is fat soluble, you should keep in mind that while taking Nefiracetam, like Aniracetam and Pramiracetam, you should take it with milk or with foods that have a high fat content.
Consulting your physician may help you determine an appropriate dosage range for you.

Sources