NALT

Background

N-Acetyl-L-Tyrosine, also known as NALT, is a modified version of the amino acid ‘L-Tyrosine’ with the active compound “acetic acid” in order to increase bioavailability and absorption [1]. As a tyrosine precursor, N-acetyl-L-tyrosine is used in place of tyrosine which is a non-essential amino acid with a polar side group. L-Tyrosine is produced in the body internally, but supplementation is often necessary to optimize cognitive function, reduce stress and increase working memory and wellbeing. N-Acetyl-L-tyrosine is administered as parenteral nutrition or intravenous infusion due to its enhanced solubility compared to tyrosine. It is typically administered as a source of nutritional support where oral nutrition is inadequate or intolerated.[2]

Benefits

NALT is an effective cognitive enhancing supplement that may promote better balance of the neurotransmitter levels in your brain. For this reason, everyone may benefit from using N-Acetyl L-Tyrosine supplements and it is a common addition to nootropic stacks with Racetams and some of the more potent brain boosters out there.
The primary benefits of N-acetyl-L-tyrosine revolve around dopamine and adrenaline metabolism. Studies suggest that NALT can increase mood in military personnel exposed to stressors like cold and altitude. The most common health benefits of NALT may include:

  • Improves cognitive function [7]
  • Improves mood [6]
  • Improve reaction time and enhance self-perceived feelings of energy and focus [6]
  • Increases concentration
  • Handles stress [8]
  • Improves memory [9]
  • People report it enhances learning capacity, general comprehension and analytical skills
  • Boosts libido [10]

N-acetyl-L-tyrosine, NALT, brings a variety of benefits to the matter for cognitive improvement and overall health enhancement. Some other benefits of this supplement include its contributions towards improving mood and alleviating the symptoms of stress and anxiety. NALT improves learning and memory skills and allows you for quicker and clearer thinking processes.[3][4]

How it works

The mechanism of action of the NALT or how actually it works within the body is a bit complex and still not fully understood. However, it is clear that NALT is an incredibly strong and bio-available form of the amino acid Tyrosine.
Through an ezymatic process, Tyrosine is converted into a versatile chemical called Levodopa (L-Dopa). Then it is used to make Dopamine as well as several other helpful chemicals involved in mental functioning. One of the things that L-Dopa does is to convert into Melanin. This process of conversion forces the removal of things called quinones which can cause neurotoxicity. Additionally, Melanin is a chelating agent within the brain, accumulating and removing harmful metals like mercury and lead. The Dopamine which is not used directly for boosting your mood is also turned into Norepinephrine.
N-acetyl-L-tyrosine, NALT, is commonly used in place of tyrosine in parenteral nutrition, but human studies carried out to date indicate considerable amounts of it are excreted unchanged in the urine. NALT retention has not been well studied in parenterally fed adults. But as used in the clinical setting, the phenylalanine and NALT composition of Aminosyn II is sufficient to meet the combined aromatic amino acid needs of adults with normal phenylalanine hydroxylase activity.[5]

Considerations

Like many other nootropic agent, N-Acetyl L-Tyrosine is considered to be very safe, non-toxic and well-tolerated in healthy adults. However, there have been some instances of side effects associated with it when it is taken at high dosage such as doses above 150 mg/kg bodyweight daily, and may cause migraine headaches, fatigue, and gastrointestinal distress such as nausea and heartburn.
The supplementation of NALT may possibly increase thyroid hormone production and perhaps interact with medications like monoamine oxidase inhibitors, synthetic thyroid hormones, and supplemental Levodopa. You are suggested to speak to a qualified health professional before combining N-Acetyl L-Tyrosine with any of these medications or supplements to avoid negative effects.

Recommendations

The typical dosage range of NALT can be between 300 and 500 mg per day and can be taken all at once or several times throughout the day. You may find that your body responds at even smaller doses or you may need more, but you should not exceed 1000 mg in a single day unless you are advised to do so by your doctor.

Sources