NADH

Background

NADH stands for “Nicotinamide Adenine Dinucleotide (NAD) + Hydrogen (H)” which is the active coenzyme form of Vitamin B3 (niacin). NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH. It is a coenzyme composed of ribosylnicotinamide 5′-diphosphate coupled to adenosine 5′-phosphate by pyrophosphate linkage.  NADH can occur naturally in the body and every cell in your body contains NADH. This compound plays a role in the chemical process that generates energy. NADH supplement is used to combat chronic fatigue syndrome (CFS). Supplementing with NADH helps improve cognitive function, mental clarity, alertness, concentration, and memory, enhance cellular energy, and increase endurance and athletic performance. This compound also helps switch ‘off’ aging genes, and increase life span.[1]

Benefits

NADH (nicotinamide adenine dinucleotide hydrogen) is an essential coenzyme which is found in all living cells. Being a powerful antioxidant, it helps eliminate free radicals and remove lactic acid build up in your muscles. During your youth, your body can produce a lot of NADH in the cells; however, as you age, your body gradually slows down to produce, and in some cases, your body may stop all together. So, supplementing with NADH can help your body stay away from diseases.
NADH has many therapeutic benefits. As a nootropic, NADH can boost ATP synthesis in your brain and increase the production of the neurotransmitters dopamine, norepinephrine and serotonin. NADH helps boost in your mental and physical energy levels, a better mood, improve cognition and alertness. It even helps relieve symptoms related to jet lag and alleviate the symptoms of Chronic Fatigue Syndrome including less brain fog. It also increases endurance during workouts and running.
The common health benefits of NADH include:

  • Improves cognitive performance [2]
  • Enhances athletic performance [3]
  • Alleviate the symptoms of chronic fatigue syndrome [4]
  • Improves learning and memory [5]
  • Enhances cellular energy [6]
  • Acts as an anti-aging [7]
  • Increases longevity [8]
  • Helps people who have Alzheimer’s disease [9]
  • Helps people who have Parkinson’s disease [10]
  • Helps with jet lag [11]
  • Reduces depression [12]
  • Improves blood pressure [13]
  • Improves physical and mental performance [14]
  • Helps with dementia [15]
  • Users report NADH increases alertness and concentration

NADH is used for relieving high blood pressure, high cholesterol, jet lag, depression, and Parkinson’s disease; opposing alcohol’s effects on the liver; reducing signs of aging; and protecting against the side effects of an AIDS drug called zidovudine (AZT). NADH is a powerful antioxidant and has its ability to eliminate free radicals. NADH may have the ability to protect cells from dying due to free radical build-up, thus breaking down the effect of aging.

How it works

NADH, Nicotinamide adenine dinucleotide (NAD) + Hydrogen (H), is a co-enzyme required for the production of energy in cells. Its effects include the stimulation of dopamine, noradrenaline, and serotonin receptors, by which mechanism it is thought to increase mental alertness and clarity and improve concentration. In small preliminary studies it has been investigated for jet lag as well as Alzheimer’s, Parkinson’s, and chronic fatigue syndrome. In the jet lag study, subjects who received NADH had significantly better cognitive performance and a trend toward reduced sleepiness on the first post-flight day than controls, and a smaller pilot study showed similar trends lasting through the second day.[16]
NADH may play a very critical role in a wide range of cellular reactions. The conversion of NAD from its oxidized form (NAD+) to its reduced form (NADH), and back, provides the cell with a mechanism for accepting and donating electrons. NAD+/NADH plays a significant role in the reactions associated with glycolysis, oxidative phosphorylation, and fermentation.[16]
There are also dehydrogenases bound to NAD and NADP in the cytosol, but due to the impermeability of the inner mitochondrial membrane to adenine nucleotides, NADH and NADPH formed in the cytosol cannot directly transfer their hydrogens to the chain.[16]

Considerations

NADH, Nicotinamide adenine dinucleotide (NAD) + Hydrogen (H), is safe and well tolerated when people use appropriately and short-term, maybe up to 12 weeks. Most people do not experience any side effects when taking the recommended amount each day, which is 10 mg. Still there are no serious reports claiming side effects that may occur. However, if you are pregnant or breast-feeding, stay on the safe side and avoid using NADH. Consult your doctor for information and medical advice about side effects of NADH.

Recommendations

There is no any standard dosage range for NADH. There can be a broad range of dosage recommendations to suit its many varied uses. Such as:
For chronic fatigue syndrome (CFS): 5-10 mg of NADH daily for up to 24 weeks. A specific product containing 10 mg of NADH and 100 mg of coenzyme Q10 has been taken twice daily for 8 weeks.
For nutrition and energy enhancement; 2.5-5 mg orally once/day to once every other day
For Alzheimer’s disease; 10-15 mg orally once/day to once every other day
For Parkinson’s disease: 10-15 mg orally once/day to once every other day
However, you are recommended to consult your doctor or healthcare provider to determine a specific dosage range for you.

Sources