Magnesium, a chemical element with symbol Mg and atomic number 12, is a shiny gray solid with alkaline earth metal. It serves as a building block for DNA and is an essential element required for proper functioning of the nervous, muscular, and cardiovascular systems.[1] Magnesium is found in every cell of the human body and its ions are essential to all living cells. Recently Scientists at MIT have discovered that magnesium supplement works as a nootropic and, when it reaches the brain, it can enhance working memory, facilitate synaptic plasticity, boost long-term memory formation and improve learning.


Among a wide range of benefits throughout whole body’s crucial functions, Magnesium supplement is mainly required by the body to digest food properly as it can help alleviate gastrointestinal discomfort and disease. It works as a co-enzyme to facilitate to break down food and assimilate the nutrients into the body. It also helps in the production of hydrochloric acid in the stomach and even triggers the healthy production of bile in the liver.
The other common health benefits of Magnesium include –

  • Calms the brain [5]
  • Improves memory, cognitive function, and focus [6]
  • Promotes relaxation and sleep [7]
  • Relieves muscle aches and relaxes arterial smooth muscle [8]
  • Reduces fatigue and increases energy [9]
  • Improves heart health and cardiovascular system [10]
  • Helps people who have migraine headache [11]
  • Helps people who have osteoporosis [12]
  • Promotes general health and athletic performance [13]
  • Reduces anxiety [14]

Another important benefit of this Magnesium supplement is the regulation of healthy blood sugar levels. Again, if you feel agitated, restless or anxious while taking other nootropics, using Magnesium supplement in a nootropic stack can improve your results. Magnesium supplementation has the ability to improve insulin sensitivity and metabolic control in type 2 diabetics. [2][3]

How it works

Magnesium is the 4th most abundant mineral in the body. It is known as a cofactor for more than 300 enzymatic reactions, and is essential for adenosine triphosphate (ATP) metabolism. Magnesium is required for DNA and RNA synthesis, reproduction, and protein synthesis. Moreover, magnesium is essential for the regulation of muscular contraction, blood pressure, insulin metabolism, cardiac excitability, vasomotor tone, nerve transmission and neuromuscular conduction.
Magnesium affects many biochemical mechanisms that are vital for neuronal properties and synaptic plasticity. Magnesium treatment reduces Aβ plaque and prevents synapse loss and memory decline in a transgenic animal model of AD. A decreased magnesium level is found in various tissues of AD patients in clinical and laboratory studies. New findings in animal studies are promising and provide novel insights in the neuro-protective effects of magnesium suggesting that magnesium treatment at the early stage may decrease the risk for cognitive decline in AD. [3]
Magnesium and some other minerals in copper are required in neuro-mineral and neuro-transmission, metabolism, as well as red blood cell (RBC) synthesis.


Being a natural supplement, Magnesium is considered to be safe and well-tolerated in normal doses. However, taking in extremely high doses, can cause the levels of Magnesium to build in the body and perhaps lead to an irregular heart-beat, low blood pressure, confusion, slowed breathing, coma, and perhaps even death. It should not be taken by people with heart block and those with kidney failure.


The recommended daily dosage of Magnesium supplement for adults can be approximately 400 mg per day. However, if you are Magnesium deficient, you can consult with your doctor to increase your dosage even more. For kids it is recommended to use less magnesium, here is a great article that explains more on this. While using Magnesium in a nootropic stack, it is recommended to combine it with Oxiracetam and the combination dosage can be 800 – 1500 mg per day.


Where to Buy

buy nootropics at amazon

Please use our link to make your amazon purchases as we use the commissions to help fund our research projects which in the end help you and the rest of the uplifted community. We do not have any affiliation with the company providing the product that we are referring you to. Our decision to find the best on Amazon is completely based on our scientific testing methods here at Nootripure Laboratories.

Here at Nootripure Laboratories we like to test supplements for potency as part of our market research and competitor analysis. We already did the research so we figured we would share with you the best products for each supplement. The quality of the magnesium mainly depends on it’s bio-availability, which is mainly determined by it’s form. Magnesium Threonate is the most bio-available form and we recommend getting a supplement that advertises that specific type of magnesium. We get commissions on any Magnesium supplement you buy on Amazon, but we would recommend the one in the link provided.