What is L-Citruline

L-Citrulline is a non-essential amino acid normally produced by the body. The body converts L-citrulline to L-arginine, another type of amino acid which improves blood flow by creating nitric oxide (NO). The name Citrulline comes from the Latin word citrullus meaning watermelon fruit which contains large amounts of the amino acid (1.1- 4.7 mg/g).[2] L-Citrulline supplement is most popularly used for sports performance, cardiovascular health, certain neurodegenerative conditions and more. Supplementing L-citrulline can help reduce fatigue and improve endurance for both aerobic and anaerobic prolonged exercise. The supplementation also increases ornithine and arginine plasma content meaning that it helps improve the ammonia recycling process and nitric oxide metabolism. People also use L-Citrulline supplement to alleviate erectile dysfunction caused by high blood pressure.[1]

L- Citruline health benefits

L-citrulline has immense health benefits from the capacity it has to increase nitric oxide (NO) synthesis in the body and induce vasodilation. Nitric oxide in your body helps your arteries relax and work better, that improves blood flow in your body. It may be helpful for hindering many diseases. The supplement can possibly help reduce blood pressure in people with prehypertension. The supplement also helps ease symptoms of mild-to-moderate erectile dysfunction (ED). Several studies suggest L-citrulline may also help people who have blood vessel problems such as slow wound healing due to diabetes. It also improves muscle protein levels and foils malnourishment in the elderly.[3] The common health benefits of L-Citrulline include:Enhance athletic performance [4] Improves immunity [5] Improves memory [6] Helps people who have Alzheimer’s disease and Parkinson’s disease [7][8] Increase exercise capacity [9] Improves erectile dysfunction (ED) and increases the hardness of erections [10] Promotes blood flow [11] Attenuates blood pressure [12] Improves heart health [13] Helps with diabetes [14] Increases growth hormone [15] Improves cognitive function [16] Reduces fatigue and improves the exercise performance of athletes [17]Some people take L-citrulline to build muscles and improve athletic performance. People also use this supplement to some medical conditions including diabetes mellitus, heart disease, erectile dysfunction, high blood pressure, vascular disease, postoperative pulmonary hypertension and dementia.

How L citruline works

L-Citrulline is one of the three dietary amino acids in the urea cycle, alongside L-arginine and L-Ornithine. The urea cycle converts a toxic compound which is known as ammonia into urea, and then it’s eliminated from the body through urine. When it is consumed, L-citrulline is converted to L-arginine by the kidneys and is released into the bloodstream by the kidneys in order that it is available to the whole body.[18[19] L-Citrulline becomes the pre-cursor to L-Arginine. Nitric oxide synthase produces nitric oxide from L-arginine. This nitric oxide plays an important role in the immune system and heart and blood vessel health. And most of the benefits of L-citrulline are because of L-arginine and nitric oxide. Getting converted into nitric acid, this compound further enhances blood flow through arteries. In the brain, the functions help support healthy neural function, especially because it pertains to memory.

Consideration abd recomendation

L-Citrulline is possibly considered very safe, and has no known side effects. However, it is important that you should not combine it with prescription medications for high blood pressure. Remember, adding this supplement may reduce blood pressure to dangerous levels.
Also, avoid taking L-Citrulline with any use of erectile dysfunction medications such as Viagra or Cialis. If you are pregnant or breastfeeding, you are advised not to take it at all.

The appropriate dose of L-citrulline may depend on several factors including the age, health, and several other conditions of the users. This dietary supplement is still not widely used by the general people. There appears to be a wide range of effective dosages, from 2 grams to 15 grams daily. A median dose of 6 grams is recommended for use in weight loss and exercise programs.


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