Gamma-Aminobutyric Acid (GABA) Benefits as Neurotransmitter Supplement

GABA Benefit for Stress Relief and Mental Health

What is gamma aminobutyric acid (GABA)

Picamilon, also known as N-nicotinoyl-GABA, nicotinyl-gamma-aminobutyric acid, pycamilon, and pikamilon, is a great nootropic drug formed by a synthetic combination of niacin molecule (vitamin B1) and GABA. It is a naturally occurring or synthetic substance that inhibits or retards oxidation reactions. This supplement is most commonly used to specifically facilitate learning or memory, particularly to improve cognitive function, and for stress relief. It is capable of relieving pain without the loss of consciousness. This drug was first developed in the Soviet Union in 1969 and later further study was conducted in both Russia and Japan as a prodrug of GABA. However, Picamilon is not approved as a prescription drug in the United States.

The common Neurotransmitter benefits of Gamma Aminobutyric Acid (GABA)

Millions of people around the world have been struggling with anxiety disorders that result in poor mental performance. Picamilon is a nootropic used for reducing anxiety disorders, stress relief, improved mental performance, and anti-aging effects. But Picamilon is most commonly known for its benefits that revolve around reducing anxiety (anxiolytic). Several studies show that Picamilon improves nervous control, recovery time after work, blood pressure and memory. Even it can help in brain trauma. The Russians use it for many different medical purposes such as relieving stroke victims, depression, asthenia, migraines and types of glaucoma. Picamilon is often compared to Phenibut which is also a GABAergic anti-anxiety supplement. But here lies a big difference and it is that Phenibut has a sedative effect whereas Picamilon does not.


The common health benefits of Picamilon include:

Reduces anxiety and depression [2]
Relieves stress [3]
Improves cognitive function [4][5]
Enhances learning and memory [5]
Enhances mental performance [6]
Is helpful for swimmers [7]
Helps with glaucoma [8]
Increases energy and extend endurance [9]
Relaxes brain and body [10]
Lowers blood pressure [11]
Relieves pain [12]
Increases of cerebral blood flow [13]
People report that it stabilizes mood, has anti-aging effects, is helpful for migraines, improves sleep

There are many nootropic users who are interested in taking Picamilon to promote their mood, alleviate stress and improve cognitive energy and focus. It may help people with anxiety, depression, sleep disorders or other mood disorders. It also enhances overall mental energy or stamina. Picamilon is also used by some people to help them overcome stress and shyness in social settings.

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Picamilon side effects

Like other nootropic supplement, Picamilon is usually safe and well tolerated by the majority of people. But it can have some adverse effects like lightheadedness, headache, nausea, irritability, low blood pressure, allergies and skin rashes or red flushing of the skin. Though they are not common, these side effects may be worse when Picamilon is taken more than recommended dosage. You are advised to consult your doctor before using Picamilon with any other medications or anti-anxiety supplements, especially other compounds that work on the GABA receptors.

Picamilon Article source

  1. https://pubchem.ncbi.nlm.nih.gov/compound/34562-97-5#section=Pharmacology-and-Biochemistry
  2. https://www.ncbi.nlm.nih.gov/pubmed/16845932
  3. https://www.ncbi.nlm.nih.gov/pubmed/16971751
  4. https://www.ncbi.nlm.nih.gov/pubmed/9621180
  5. https://pubchem.ncbi.nlm.nih.gov/compound/Pikamilone#section=MeSH-Pharmacological-Classification
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056667/
  7. https://www.ncbi.nlm.nih.gov/pubmed/19803364
  8. https://www.ncbi.nlm.nih.gov/pubmed/23808185
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056667/
  10. https://www.ncbi.nlm.nih.gov/pubmed/16971751
  11. https://www.ncbi.nlm.nih.gov/pubmed/3709776
  12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918363/
  13. https://www.ncbi.nlm.nih.gov/pubmed/2707413

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