Fladrafinil, (the chemical name for the smart drug is CRL 40941, and also known by another name called fluorafinil), is a eugeroic closely related to adrafinil and modafinil. An interesting fact is that modafinil is the popular version of fladrafinil and the bis(p-fluoro) ring-substituted derivative of adrafinil. Fladrafinil was first found in the 1970s together with a range of similar nootropics and could produce anti-aggressive effects in both animals and humans, which adrafinil could not produce.[1] It is a powerful and legal analogue of modafinil that allows the user increased focus, memory and cognition.


Being a wakefulness-promoting smart drug, you can make a successful use of fladrafinil as a nootropic for promoting wakefulness for people who find themselves feeling overly sleepy and tired throughout their day due to sleep disorders like sleep apnea and narcolepsy.
Fladrafinil has similar cognitive effects to those listed for Adrafinil. The cognitive effects include improved memory and recall speed as well as a possible increase in learning capacity. As the attention period is also expanded, you will have the ability to concentrate and focus. You will also find it easier to engage in common tasks like reading, writing, talking, and giving presentation. Students use fladrafinil as a study pill, for alertness and staying awake for all-night cram sessions before an important exam. The benefits of fladrafini include –

  • Promotes Wakefulness[4][5][9]
  • Increases Alertness[6]
  • Heightens Concentration and Focus[7]
  • Improves Memory and Recall[7]
  • Enhances Learning Capacity[8]

How it works

Figure 1: Fladrafinil chemical structure

Fladrafinil, or CRL 40941 has neuropsychopharmacological properties similar to those of adrafinil, or CRL 40028 which is a known psychotonic agent. It is different from the latter by its anti-aggressive properties and its effect with reference to electric shock. It is also observed that Fladrafinil or CRL 40941 presents another advantage over adrafinil regarding assimilation by the oral route; in fact, fladrafinil, as psychotonic agent, is clearly almost two times effective by the oral route, in the rat and in man, than adrafinil.[2][3]
The liver helps to metabolize fladrafinil into its useful form of modafinil. It helps people with improving the way their brain operates as they are trying to focus and retain alertness. Fladrafinil also affects the central nervous system and helps to prevent the reuptake of dopamine in the brain. Though it is not fully clear how this class of drugs works, it has been proven to help people overcome their daytime sleepiness or work third shift jobs without feeling sleepy during their night shift.


Side effects of SAMe are rare, and when they do occur they are usually minor problems such as nausea, digestive upsets, headache, restlessness, and insomnia. Although SAMe has been used to treat cholestasis during pregnancy, its safety during pregnancy has not been established. Again, SAMe may decrease the effects of levodopa (L-dopa), a drug used to treat Parkinson’s disease. It’s also possible that SAMe might interact with drugs and dietary supplements that increase levels of serotonin (a chemical produced by nerve cells), such as antidepressants, L-tryptophan, and St. John’s wort.[8]  So, it’s always wise to consult an experienced physician before starting any supplement.


Remember that fladrafinil is more potent than adrafinil. New users are recommended to start with the dosage 30-80 mgs within 14-16 hours daily, and an adrafinil moderate dose is between 30-100 mg per day. The dosage may be increased when the effects are being experienced as the body reacts towards the dose. But dosage should not exceed 200mgs per day.