What is Fasoracetam

Fasoracetam, (also known as NS-105, LAM-105) with a chemical structure of (5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-one, is a powerful nootropic compound of the racetam-class family. Initially developed for dealing with Alzheimer’s Disease by Japanese pharmaceutical company Nippon Shinyaku, this nootropic supplement appears to improve the symptoms of ADHD in adolescents. Fasoracetam has been very much popular with college students for its potent effects to enhance memory and cognition.[1]

Fasoracetam Health benefits

Like many the nootropics, Fascoracetam appears to be a distinct benefit to patients with diseases and conditions that affect the brain and memory. It has proven to show benefits for people suffering from conditions like schizophrenia. However, the greatest benefit of Fasoracetam can be seen in patients with Alzheimer’s disease, helping to reduce the expected loss of mental acuity and memory. It may also be beneficial for some of the young patients who are affected by varying degrees of Attention Deficit Disorder or Attention Deficit Hyperactivity Disorder, or as they are more commonly known, ADD and ADHD.  The following are some of the health benefits of Fasoracetam studied and observed in animals –

  • Decreases ADHD symptoms in adolescents [2]
  • Improves memory and learning [4]
  • Enhances cognitive performance [5]
  • Shown to restore memory after being impaired by baclofen [6]
  • People report it acts as an antidepressant
  • People also report it improves mood, motivation, and creativity
  • Studies have shown fascoracetam to decrease apathy [7], depression [8], and anxiety [9].
  • Hinders amnesia with cholinergic dysfunction [10]

It is currently gaining interest from nootropic users primarily because of its potential effectiveness in the case of ADHD. Fasoracetam helps boost memory, melt away procrastination, improve focus, relieve depression and enhance learning. It is also a powerful antidepressant and anxiolytic. Though it is young, Fasoracetam may likely become beloved members of many nootropic stacks.[3]

How fasoracetam works

Fasoracetam works mainly on three different types of receptors in tandem: increasing glutamate activity, upregulating GABAB receptors and increasing acetylcholine release and synthesis. Fasoracetam is purported to increase glutamatergic activity and was found to significantly reduce the symptoms of ADHD in adolescents. In the cerebral cortex and the hippocampus, fasoracetam increases high affinity choline uptake (HACU) which increases acetylcholine synthesis. Additionally, there is an increase in acetylcholine release in the cerebral cortex. Fasoracetam inhibited baclophen-induced memory loss in rats whereas the other drugs used did not. This further suggests it has a potent influence on cholinergic and GABA systems, both of which, in varied and complex ways, retaining new information. Fasoracetam binds to the GABAB receptor in rats effectively blocking the memory disruptions caused by baclofen. However, it’s not clear whether it activates the receptor (agonist), blocks it (antagonist), or acts in a more complex-manner, i.e. partial-agonist or inverse agonist.[3]

Consideration and recommendation

Due to the sufficient number of lack of studies, Fasoracetam has not been approved or regulated by the FDA, or entirely, encouraged by the medical community. The most common side effect associated with fasoracetam supplementation may be headaches. Although it is relatively safe for human use, some people might develop allergic reactions towards its components. Hence, it is highly recommended that you take great precautions before using fasoracetam. Pregnant and lactating mothers, as well as individuals suffering from any medical condition or are currently taking other medicines are not advised to take fasoracetam.

There are not many of studies of Fasoracetam supplementation about the proper dosage and recommendations for taking.  Although some studies have shown that 100 mg does not cause any severe untoward effects, experts suggest that 10 mg a day sublingually is effective in producing its effects. Make sure that you don’t exceed the recommended dosage since fasoracetam is notably as potent as noopept. And this puts its potency level in line with nootropics like Noopept which are said to be 1000x stronger than Piracetam.


mind/the-hopeful-adhd-implications-of-fasoracetam-8b28b8e84cbc https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770454/ http://www.sciencedirect.com/science/article/pii/S0091305799001082 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770454/ https://www.ncbi.nlm.nih.gov/pubmed/9424016 https://www.ncbi.nlm.nih.gov/pubmed/10494996 http://www.longecity.org/forum/topic/69555-fasoracetam/page-2 https://www.ncbi.nlm.nih.gov/pubmed/9424016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770454/ https://www.ncbi.nlm.nih.gov/pubmed/10494996