How to Cycle Nootropics to Avoid Tolerance


Developing tolerance is great in our real life situations, but what are the consequences in the case of nootropics?
In the cases of nootropics and other pharmaceuticals, it means that over time, through a number of biological adaptations, your body will respond to the substances you are consuming by making them increasingly less effective. You may notice that you do not experience the same benefits as you did when you first started using the same nootropics.  As this is unavoidable, your body naturally seeks homeostasis, or the regulation of variables in order that the internal condition remains stable and regular. Meaning, your body adapts. Generally, homeostatic mechanisms include blood pressure regulation, fluid balance, temperature control, hunger, energy balance, and (specifically relating to nootropics) neurotransmitter balance. This may be accomplished through many routes, from downregulating receptors to decreasing the amount of neurotransmitters produced, but the end result is the same: the body often finds a way to neutralize the effects of the nootropics it gets used to. In such a situation, to achieve the same effects as before, you need to take more and more, continually increasing your dosage. This is a bad idea because it is not only potentially dangerous but also counterproductive in the long run. Your body develops tolerance as with the increased number of dosages and puts up defenses to biologically block the effects you’re looking for.

The Relationship Between Tolerance And Addiction

Tolerance and addiction are not equal but a fairly grim point that tolerance can become addiction. You may temporarily go for repeatedly increasing more dosages of the substance that you are consuming simply to compensate for tolerance. But your body also continues to adapt to whatever is disrupting homeostasis. The more you increase the dosage of the substance, the more your body produces its tolerance to render it less impactful. When this cycle goes on continuously, your body can start automatically churning out greater amounts of whatever chemicals it assumes it will need to maintain homeostasis. Soon you will also discover yourself in a situation necessary to take the substance so as to counteract the body’s resistance and simply feel normal. However, keep in mind that addiction isn’t looming over everyone who takes any substance intended to improve their mental or physiological performance in some way. Everyone’s reaction to substances is widely different. And this is only the case with some substances such as caffeine or nicotine.

Avoiding The Tolerance Trap: Start With Cycling

As tolerance is to be sure a reality in the world of nutritional supplementation, what can you do to avoid this potential effect? The first thing may be to understand what the prospects are of developing nootropic tolerance. You can start by research and personal monitoring as well as learning as much as possible about the nootropics you’re taking; reading articles and posts about a particular nootropic will give you an idea of how it affects other users and what their experience was in terms of tolerance and effective cycling. Since everyone’s body reacts differently, there are no universally accepted recommendations for nootropic cycles.  However, cycling is mainly establishing a pattern of taking the nootropic for a specific number of days, weeks, or months, followed by a set amount of time when you don’t take it. For instance, you are recommended that if you take a nootropic for 3 months with successful results and started to experience signals of tolerance in the month 4, you can abstain from taking for a full month before starting to take it again. Similarly, when you start to experience signs of tolerance after 2 or 3 weeks of continuous use, you may proceed on a one week on, one week off cycle. Your close monitoring is very important and whenever you notice the beginnings of tolerance developing, you can temporarily discontinue taking. While taking two nootropics having similar mechanisms of action (for instance, two stimulants), discontinuing one but continuing to use the other may or may not resolve any tolerance issues you’re experiencing.

Recommendations, Dosages and Smart Stacking

Though a perfect, one-size-fits-all method for cycling nootropics is not available, you may find some general helpful guidelines on many perspectives cycling in two of the Internet’s largest nootropic communities, Reddit’s r/nootropics and Longecity’s Brain Health Forum. Keep in mind, they are just some common practices based on individual experiences. According to user reports posted on forums in nootropic communities, the following are the suggested common cycling schedules:


Either limit to 2-3 times per week or a cycle of 1 week on 2 weeks off. Not recommended for long-term use.


Anxiolytics like phenibut tend to produce tolerance and may come up with best results when used only a few times a week. It is generally recommended to wait a minimum of 2-3 days between doses.


A good starting point for racetam family nootropics such as piracetam, pramiracetam and aniracetam is a cycle of 3 to 4 months on and 1 month off, while pramiracetam and oxiracetam may yield best results with a shorter cycle of 3 to 4 weeks on and 1 week off. Racetams with more stimulative properties such as phenylpiracetam and oxiracetam may prove most effective with non-daily use.


It may be recommended to take for 2-3 weeks on and then, if necessary, another cycle after a 1 week break. Many nootropic users also follow a cycle of 56 days on and 4 days off.


3-5 times per week.


Cycling choline sources isn’t generally regarded as necessary.
Creating smart stacks of essential nutrients is important and it will increase the performance of your nootropics. Including high quality Choline like CDP Choline or Alpha GPC may significantly improve the length of time you can take the nootropic supplement before experiencing signs of tolerance. You may not find a way of avoiding tolerance completely by cycling nootropics but you can minimize tolerance-related problems intelligently by doing some research and paying close attention to your own responses.

Our Thoughts

We consider cycling nootropics very important as our aim is to keep the mind in its most natural and balanced state. In each of our products and supplementation programs that go along with them, we design with cycling as one of the foremost factors in creating an optimized lifestyle. This ensures that our customers will be able to use our products with decreased risk of side effects, a heightened receptivity to the product’s formula, and most importantly, long term sustainable health. If you are not using our products, we recommend that you at least follow basic cycling practices to ensure consistent enjoyable usage of nootropics.