Alpha GPC

Background

Alpha-glycerophosphocholine, also known as Alpha-GPC or α-GPC, and choline alfoscerate, is a natural cholinergic compound and a natural nootropic used for its cognitive-promoting properties, and to enhance performance in athletes. Alpha-GPC is also a parasympathomimetic acetylcholine precursor that may may be a thing for the people who have Alzheimer’s disease and other dementias. Although it is found in a variety of food products that are also rich in choline, the nootropic supplement is very effective and it also appears to support cellular membranes, and may aid in relieving people of cognitive decline.[1]

Benefits

Known as a powerful memory booster, Alpha-GPC itself or when in stacks with other nootropics, especially with racetams, is a great potentiator that can take cognitive enhancement to a new level. The principal benefit of alpha GPC is as a pro-drug for choline used by the brain for a chemical called acetylcholine which is implicated in memory, focus, reasoning and learning. It also causes a reduction in cognitive decline, which is seen in both the elderly and healthy adults alike. Some of the amazing health benefits of Alpha-GPC include –

  • Improves memory, thinking skill, learning and recall  [4]
  • Reduce memory impairments and helps people who have Alzheimer’s disease [5]
  • Increases expression of the dopamine and serotonin level [6]
  • Protects overall brain health [7]
  • Increases physical performance [8]
  • Increases endurance performance and growth hormone secretion [9]
  • Enhances cognitive areas such as mood and memory [10]
  • Helps people with stroke and mini-stroke [11]
  • People report it increases focus and attention
  • Increases growth hormone, strength, and fat oxidation [12]

The dietary supplement of Alpha-GPC may also promote better health of your neurons and may be able to protect and repair damaged cells. It may even improve the effectiveness of communications between neurons within the brain. As a result, there is a boost to your memory and creativity, better learning and studying abilities, faster speed of thought, and increased mental clarity.[2][3]

How it works

Alpha GPC is a water soluble supplement and fast acting and with highly bioavailability when taken orally. It quickly crosses the blood-brain barrier following oral ingestion to deliver choline to neural tissues and increasing levels of the neurotransmitter acetylcholine.
Alpha GPC also stimulates increased vesicular acetylcholine transporter (VAChT) expression and choline transporter (CHT) expression in all brain areas known as hippocampus. These presynaptic cholinergic transporters are quite responsible for sustaining ACh synthesis and release from neurons.[4]
Alpha GPC provides extra choline that makes it a valuable part of a nootropic stack, particularly in combination with racetam class supplements such as piracetam, pramiracetam, oxiracetam, aniracetam. These nootropics act by stimulating acetylcholine receptor sites, that makes maintaining a sufficiency of choline in the brain important. Alpha-GPC also serves as a pioneer for phospholipids in neural membranes and is believed to improve neuronal functioning by improving neuronal membrane fluidity.

Considerations

When used appropriately, Alpha-GPC seems to be safe. Like some common nootropics, it may cause side effects in some people including heartburn, headache, insomnia, dizziness, skin rash, and confusion. It is better to stay on the safe side and avoid use during pregnancy and breastfeeding.

Recommendations

Alpha GPC is generally well tolerated when taken at recommended dosages. With nootropic stack, you are recommended to take a dosage of 300-600 mg to start out and then to increase from there if you decide you would benefit from more. Though, for most adults, the acceptable dosage range can be 300 mg to 1,200mg per day, taken 2-3 times a day, it is wise to start with the lowest possible effective dosage and then gradually increase.

Sources