Acetyl-L-Carnitine  also known as ALCAR is a true multi-purpose nootropic supplement which is used for two main functions – for energy boosting and improving brain and mental function. It is an acetylated form of L-carnitine  produced naturally by the body though it is often taken as a dietary supplement. Contrary to L-Carnitine, Acetyl-L-carnitine is able to go through the blood-brain barrier and deliver its payload to the brain where it can be utilized to increase energy metabolism in the brain cells.[1]


Acetyl-L-Carnitine is a powerful antioxidant and neuroprotectant known for its great nootropic properties and has immense benefits on both brain and body. Acetyl-L-Carnitine works as cognitive booster. Multiple studies show that it successfully reduces mental fatigue and enhances cognition and improves learning ability.
One of Acetyl-L-Carnitine’s most exciting prospects is it is used by people who have age-related neurological disorders including Parkinson’s and Alzheimer’s diseases. Studies also show that Acetyl-L-Carnitine helps restore ambulatory capability in the elderly people and acts as a mood elevator and reduces depression in the aged people.
The common health benefits of Acetyl-L-Carnitine include:

  • Improves cognitive performance [2]
  • Helps people who have Alzheirmer’s disease [3]
  • Improves memory and learning [4]
  • Reduces depression [5]
  • Promotes thinking problem [6]
  • Increases fertility [7]
  • Increases noradrenaline and serotonin content [8]
  • People report it enhances endurance
  • Enhances weight Loss [9]
  • Helps people in muscle damage [10]
  • Amps up fat burning [11]
  • Boosts brain function [12]
  • Regulates blood sugar and helps people who have diabetes [13]

Significant evidence says that Acetyl-L-Carnitine can be of considerable benefit to people with physical disorders typically associated with aging, including high blood pressure, diabetes, and metabolic syndrome. It has proven to be effective in relieving nerve pain, improving kidney function, promoting heart health, mental clarity, memory, concentrative ability and the feeling of being mentally energized.

How it works

Acetyl-L-Carnitine supplementation is well-known to enhance the action of some significant nootropics like those in the racetam family. Acetyl-L-Carnitine acts as a precursor to acetylcholine, an important neurotransmitter for memory consolidation and recollection ability. It combines with choline in the brain to produce this brain chemical that is then used to store memories as well as in directing attention and ignoring distractions.
Acetyl-L-Carnitine also targets brain metabolism, enhancing cellular energy and acting as an effective neuroprotectant. Its significant antioxidant properties fight the effects of cellular oxidation and decrease the number of damaged cells in the brain, making Acetyl-L-Carnitine a powerful anti-aging supplement.
While supplementing Acetyl L-Carnitine with a choline source like Citicoline or Alpha GPC, you will experience healthy improvements in your ability to remember newly presented information as well as accessing seemingly forgotten memories.
When taken alone, Acetyl L-Carnitine is effective in many respects, but its nootropic properties are most pronounced when it is taken in combination with other nootropics. In many cases the combination of Acetyl L-Carnitine with other nootropics is equally potentiating, making all the compounds in the combination or stack work better and more efficiently than they would discretely.


Acetyl-L-Carnitine is exceptionally safe and well tolerated and side effects are rare. Still some common side effects such as nausea, headaches can usually be addressed by taking Acetyl-L-Carnitine with food or excess choline or if it is associated with high dosage.


It is recommended for nootropic purposes that usually a dose of 250-500mg of Acetyl-L-Carnitine, divided into 2 equal doses throughout the day will produce beneficial results. It is considered a key element in nootropic stacks as it works best in combination with other smart drugs. Taking Acetyl-L-Carnitine late in the evening may cause disruption of the normal sleep cycle. It can be taken on an empty stomach, but users who experience gastrointestinal upset report that it can be minimized or avoided by taking Acetyl-L-Carnitine with food.